Structure of PDB 6y2l Chain SS Binding Site BS01

Receptor Information
>6y2l Chain SS (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTK
RAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLD
NKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT
Ligand information
>6y2l Chain S2 (length=1713) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucg
augguagucgccgugccuaccauggugaccacgggugacggggaaucagg
guucgauuccggagagggagccugagaaacggcuaccacauccaaggaag
gcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaa
aaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccac
uuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcag
ccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaa
aagcucguaguuggaucuugggagcgggcguccccgccccucucggcgcc
cgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgcgggcagcuuccggg
aaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacu
uaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaau
uugacucaacacgggaaaccucacccggcccggacacggacaggauugac
agauugauagcucuuucucgauuccgugggugguggugcauggccguucu
uaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucu
ggcaugcuaacuaguuacgcgacccccgagcggucggcguccaacuucuu
agagggacaaguggcguucagccacccgagauugagcaauaacaggucug
ugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcuca
gcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccau
ucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucc
caguaagugcgggucauaagcuugcguugauuaagucccugcccuuugua
cacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucgga
ucggccccgccggggcccuggcggagcgcugagaagacggucgaacuuga
cuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugc
ggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<....<<<.<<....
...>>.>>.>....>>.........<<<<...<<<<........>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....
<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....
>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>
...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.
>.....<<.<<<<<<............>>.>>>>..>>......<<..<.
..........>..>>.........<<<<<((......<<<<.....<<..
))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((...
..<.<<...<<<.<<........<..........>...............
........<<<<<<.<.......<<...<.......>.<<<<.......>
>>>...>>......>.>>>..>>>........<.<<.<<<<<<.......
..........>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<
<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>......
.<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<
<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
.<<.<<<..<.<.<<<<.<<<<......>>>>>>>>>.>..>>>...<<.
.))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>
>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<.......
.<<........>>..........<<<<<......<<<<<<.......<<.
<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<..
..<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<.
..<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..>>>>..>>
>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...
..>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<....
....<.......<<<.<<<<....>>>>.>>>....>.........>>>.
>>............<<<<<..........>>>>>...........>>>>>
.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.
>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...
<<<<<......................>>>>>...>>.>>>>..>>>.>>
>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>
>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6y2l Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K25 F28 K34 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 R86 Q87 K88 D110 H120 R121 R124 H125 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 G140 R141 G143 R144 T145
Binding residue
(residue number reindexed from 1)		K21 F24 K30 G31 V32 G33 R34 R35 Y36 R51 W78 F79 N81 R82 Q83 K84 D106 H116 R117 R120 H121 R126 V127 R128 G129 Q130 H131 T132 K133 T134 T135 G136 R137 G139 R140 T141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6y2l, PDBe:6y2l, PDBj:6y2l
PDBsum6y2l
PubMed32268098
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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