Structure of PDB 8ovj Chain SR Binding Site BS01

Receptor Information
>8ovj Chain SR (length=135) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLTLIPDHFQHIVRLLNTNVEGKRKVPFALRMVKGVGIRFAYLVCKKAGI
DVERRAGTLTAEELEKIAEIIADPAKFKIPDWFLNRQRDPKTGKTEHLSS
SMVDTRLRDDLERLKKMRAHRGVRHAYGLRVRGQH
Ligand information
>8ovj Chain S1 (length=1755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggc
gaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccag
cgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguuga
cucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacug
cccuaucagcuggugauggccguguaguggacugccauggcguugacggg
agcgggggauuaggguucgauuccggagagggagccugagaaauagcuac
cacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaa
acgaugaggcagcgaaaagaaauagaguuuuucaaugggggauauuuaaa
cccauccaauaucgaguaacaauuggaggacaagucuggugccagcaccc
gcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaagg
guucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacac
gggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacu
aaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggaua
acaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugc
uuucccaucucggugugggguuuacggccucuaggaaugaaggaggguag
uucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcac
caagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaa
gaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacac
ugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuu
uuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaag
agugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgug
cgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaug
aggauugacagauugaguguucuuucucgauucccugaaugguggugcau
ggccgcuuauggucgguggagugauuuguuugguugauuccgucaacgga
cgagauccaagcugcccaguagaauucagaauugcccauaggauagcgca
uucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaacuacuugaucaaaagaguggggaaacc
ccggaaucacauagacccacuugggaccgaggauugcaauuauuggucgc
gcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacg
ucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaa
uacaggugaucggacagggcccgaaaguucaccgauauuucuucaauaga
ggaagcaaaagucguaacaagguagcuguaggggaaccugcagcugggac
auuuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<
.....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<
<<<<<<<<<.....((.((.{..{<<.>>.....................
....>>>>>>>>>>....<<<<<...>>>>>...>>.>>..>>>>..>>>
.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>
..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>
>.<<<<<..>>>>>...>>>>>>.........<<<....<<<........
..>>>..>>>..>....>>>....<<<...>>>.....<<<<........
....>>>.....>.........<<<<<((....<.<<<<.....<<..))
>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....
<<<<...<<<.......<.............>............<.....
...........<<<<.......>>>>.........>...<<<<<<<<...
....<<...<.......>..<<<..>>>.....>>......>>>>>..>>
>..........<<.<<.<<...}..}.)).))...>>.>>.>>.......
.......<...<.<....>.>....>..................<<<<<.
.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>
>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...
>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
>.........<<<.<<.<.<...<<<<<<...........>>>>>>...>
.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<
<<<<......<<........>>..........<<<<<.<....<<<<...
......<<.<<<........>>>.>>.......>>>>.<.<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<<<.....<<<<<<<.<<<<.................>
>>>.>>>>>>>.....>>>>....<<<<........>>>>.......>>>
>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<..<<.<.<..........>.>.>>...>.
.......>>>...>>>......<....<<<..<..........>..>>>.
....>.....>>>>>>....<<<<<<<.........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<
<<..<<<<<.<...<.<...>.>...>.>>>>>..>>>>.>.>>>.>>..
>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		K26 F29 R32 K35 G36 V37 G38 R40 F41 R56 W83 F84 N86 R87 Q88 R89 D111 H121 R122 R131 V132 R133 G134 Q135 H136
Binding residue
(residue number reindexed from 1)		K25 F28 R31 K34 G35 V36 G37 R39 F40 R55 W82 F83 N85 R86 Q87 R88 D110 H120 R121 R130 V131 R132 G133 Q134 H135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4Q1Y3

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