Structure of PDB 8xt2 Chain SQ Binding Site BS01

Receptor Information
>8xt2 Chain SQ (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDA
LQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAGTT
YLESPLS
Ligand information
>8xt2 Chain S1 (length=928) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagauc
acaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaa
aauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaaga
cccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacag
uucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaa
aggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucg
auaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccau
cuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacgua
aagacguuaggucaagguguagcccaugagguggcaagaaaugggcuaca
uuuucuaccccagaaacgauagcccuuaugaaauaagggucgaaggugga
uuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagc
gcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauua
acuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaa
guguacuggaaagugcacuuggacgaac
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<....<<..>>....>>>...<
<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<..
....<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.....
........<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<.
..<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<
<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..
>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<
........>>..........<<<<<<<.......<<.<<<..<<<<<<..
.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>
.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>...
..<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....
>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>
>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.
....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<
<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S7 H9 K21 M22 Q23 K24 T25 K27 Y38 N44 R46 R73 A74 K75 H76 V77 K78
Binding residue
(residue number reindexed from 1)		S3 H5 K17 M18 Q19 K20 T21 K23 Y34 N40 R42 R69 A70 K71 H72 V73 K74
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtQ9Y2R5|RT17_HUMAN Small ribosomal subunit protein uS17m (Gene Name=MRPS17)

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