Structure of PDB 8tpu Chain SQ Binding Site BS01

Receptor Information
>8tpu Chain SQ (length=144) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSGKPSGLRAARKLRIRRRTQRWADKSYKKSHLGTRWKSNPFRGSSHAKG
IVVEKVAIEAKQPNSAYRKCVRVQLIKNGKKITAFVPGDGCLNFIDENDE
VLVSGFGRSGHSVGDLPGVKFKVVKVARVSLLALFKEKKEKPRS
Ligand information
>8tpu Chain SA (length=1608) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagcc
augcaagugaaaguauauauauauauauguagaaacugcgaacggcucau
uaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagc
uguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaa
uuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugacc
uaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaa
cggggaauuagaguucgauuccggagagggagccugagaaauagcuacca
caucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagaga
gguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaau
uuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagc
cgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaa
cgcucguaguugaauuucaaagaaucauucuuuuuaaaauccgauuuugu
uacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguu
ugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuugu
ucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucgu
auucagaugucagaggugaaauucuuagauuuucuggagacgaacaacug
cgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagg
gagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccga
cuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagu
cuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauu
gacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaac
acggggaaacucacuaguuuaagacauuggauggugaugcauggccguuu
uuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuu
aaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaa
cauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugaug
uccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgag
uaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuu
aucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaa
cgaggaaugccuaguaagcaugauucaucagauugugcugacuacguccc
ugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaug
aauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucu
uuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcgga
aggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<...
.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>
>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<.....
.>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<
<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..
>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.
........>>>>>>.........<<<<<((......<<<<.....<<..)
)>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((....
.<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<.>>.>>><<
<<<<.<<.......<<...<.......>..<<<.......<<...>>>>>
....>>......>>.>>..>>>>.....<<<<<.<<...<<<.<......
....>.>>>...>>.>>>.>>.>>....<<<<<<..<<..<<<<<..<<<
.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<
<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<.
..<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<
<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>
.....>>>.>>>.<<<.....<<<<<....>>>>>...>>>..)))).]<
<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<<<....<<.>>...<<.<<<..<<.<<<<<<.
...<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<
<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>..
..<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>
>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<......<<
...<.<<<<<..>>>>>.>...<<<.<<<<....>>>>.>>>....>>..
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<.
.<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>
>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>
>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tpu Divergent translational landscape reflects adaptation to biased codon usage in malaria parasites
Resolution4.1 Å
Binding residue
(original residue number in PDB)		G2 S3 G4 K5 P6 S7 G8 L9 R10 R13 K14 R18 R19 R20 Q22 D26 K27 K30 G35 W38 K39 S40 S46 S47 H48 A49 K50 K62 Q63 N65 S66 Y68 R69 K70 D90 G106 R109 S110 H112 V114 G115 D116 K126 S131 K140
Binding residue
(residue number reindexed from 1)		G1 S2 G3 K4 P5 S6 G7 L8 R9 R12 K13 R17 R18 R19 Q21 D25 K26 K29 G34 W37 K38 S39 S45 S46 H47 A48 K49 K61 Q62 N64 S65 Y67 R68 K69 D89 G105 R108 S109 H111 V113 G114 D115 K125 S130 K139
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