Structure of PDB 8fkr Chain SQ Binding Site BS01

Receptor Information
>8fkr Chain SQ (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKSKRDKKVSLTKTAKKGLELKQNLIEELRKCVDTYKYLFIFSVANMRNS
KLKDIRNAWKHSRMFFGKNKVMMVALGRSPSDEYKDNLHQVSKRLRGEVG
LLFTNRTKEEVNEWFTKYTEMDYARAGNKAAFTVSLDPGPLEQFPHSMEP
QLRQLGLPTALKRGVVTLLSDYEVCKEGDVLTPEQARVLKLFGYEMAEFK
VTIKYMWDSQSGRFQQM
Ligand information
>8fkr Chain L3 (length=1767) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaccucagaucagacguggcgacccgcugagcauauuagucagcggag
gagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaag
agcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgg
aagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucg
aggcccagcccguggacggugugaggccgguagcggcccccggcgcgccg
ggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgg
gugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaagua
ccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgu
gaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagcggcgacgucggcuacccacccgacccgucuacacggaccaaggagu
cuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaag
gugggaucccgaggccaguccgccgagggcgcaccaccggcccgucucgc
ccggggagguggagcacgagcgcacguguuaggacccgaagcugguuccc
uccgaaguuucccucaggauagcuggcgcucucgcaguuuuauccggggu
aagaagcccggcucgagccgggcguggaaugcgagugccuagugggccac
uuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaag
gcgcccgaugccgacgcucacccagaaaagguguugguugauauagacag
caggacgguggccauggaagucggaauccgcuaaggaguguguaacaacu
caccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucggg
cccauacccggccgucgccggcagucgagaguggacggcgcggacgcuac
gccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgc
gggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaug
uuggaacaauguaggaccuacuauccagcgaaaccagccaagcuuggcuc
agccuggcuuguggcggccaagcgcgacgucgcuuuuugugugaagcaga
auucaccaaacugaugauguguuguugccaugguaauccugcucaguacg
agaggaaccgcagguucagacauuugguguaugugcuuggcugaggagcc
aauggggcgaagcuaccaucugugggauuaugacugaacgccucuaaguc
agaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccuc
ggauagccgguccccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcac
guucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucg
ggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagag
cccucgacacgguuugu
........................<<<<<<.............>>>>>.>
.........<<....>>..<<<<<<.....<<.....>>....>>>>>>.
.<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<
<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>
>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>
>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<
<<<<.>>>>>>..>>>..................................
<<....>>...............<<<<....>>>>...............
................<<<<<<<<..<<<......<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<...<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>.>>>>>>....>>>...>>>>>>>>..<<<<....>>>><<<<<<....
<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<
<<<<...<<<..<<........>>..>>>....>>>>>.<<<<<<<<<.<
<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...>.>>..<<<
<<<......<<<....>>>..<<.<<<<<<<..<<<.<<<<<<<<.>>>>
>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.
<<<<<...[[>>>>>.>>>>....<<<......>>>...<<<<<<<...<
<<(((.......<<<<<....<<<....<<<.<<<<<<<<<<.......<
<<<<.<<<...<<.........>>...>>>.........<<......>>.
..>>>>>...>>>>>>>>>>>>>.....>>>..)))......>>>>>..>
>>...>>>>>>><<<<<<.<<<..............<.>...........
>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<..
..>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<.....
.<<<<.....<<<<<.>>>>>..>>>>.>....>>.<<<<<<>>>>>><<
<<.]].......<<<<<<...<..>...>>>>>>......<<<<<.....
.>>>>>....>>>>......<<<<<<.<..<<<..<.<<<<<........
.........>>>>>.><<<<....<<<<...<.<..<<<<<<....>>>>
>>....>...>>>>>...>>>><<<<<...<<<<<...........>>>>
>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<...
.....<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>........
......>>>>..>>>>>>>>.<<<<<.<.............>....<<<<
<<<<<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>.>
>>>>.>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fkr Principles of human pre-60 S biogenesis.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		P2 K3 S4 K5 R6 D7 K9 L12 T13 K14 T15 A16 K17 K18 L22 K23 R49 N50 K54 R57 R64 F67 G68 K69 N70 R126 S148 M149 Q152 P184 R188
Binding residue
(residue number reindexed from 1)		P1 K2 S3 K4 R5 D6 K8 L11 T12 K13 T14 A15 K16 K17 L21 K22 R48 N49 K53 R56 R63 F66 G67 K68 N69 R125 S147 M148 Q151 P183 R187
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030687 preribosome, large subunit precursor

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fkr, PDBe:8fkr, PDBj:8fkr
PDBsum8fkr
PubMed37410842
UniProtQ9UKD2|MRT4_HUMAN mRNA turnover protein 4 homolog (Gene Name=MRTO4)

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