Structure of PDB 8btd Chain SQ Binding Site BS01

Receptor Information
>8btd Chain SQ (length=127) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEAFAVCHIYAGKNDTFIHVTDLSGRETIGRVSGGMKVKRHCDEPSAYAA
MQATQDLIEIITDRGITAVHIKIRADGGTGKRVYGGGSAAGIRALVRGGI
KIGRIEDSTPIPTDRTRHKGGRRGRRL
Ligand information
>8btd Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<.........<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<..............<<.....<<<<<<....>>>>>>..
....>>........<<..<<<<...[.....<.....>..>>>>.>>...
.......>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>......>>>>>............<
<<<<<.........>>>>>>.....<<<<<<<.........[.....((.
.>>)).......]....>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<...<.......
>............>>......>>>>>..>.>>>..<<<<<<.......].
.>>>..>>>..........<<<<<<<.<...<<<<..<<..<<<<<.<<<
..<..........>.....>>>.>>>>.>.>>.......<<....>>...
>>>>..>.>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<........<<........>>........
.<<<<<......<<<<<<......<<..<<<.......>>>..>>....>
>>>>>...<<.<<<.....<<<<<<....<<.<<<<<<....>>>....<
<......>>....>>>.>>....<<<...<<<<<.....>>>>>.....<
<<<<....>>>>>.........>>>....>>>.>>>.......>>>>>..
.....>>>>>......>>>>.>>>.....<<<.<<<.....<.<<<.<<.
...>>.>>>..>....>>>.>>>......<....<<.<<<<......>>>
>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....
....
Receptor-Ligand Complex Structure
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PDB8btd Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution4.9 Å
Binding residue
(original residue number in PDB)
H32 K37 N38 F41 H43 S48 G49 R50 E51 T52 R55 G59 M60 H65 C66 E68 R88 P134 I135 P136 T137 D138 R139 T140 R141 K143 G144 R146 R147 R149 R150 L151
Binding residue
(residue number reindexed from 1)
H8 K13 N14 F17 H19 S24 G25 R26 E27 T28 R31 G35 M36 H41 C42 E44 R64 P110 I111 P112 T113 D114 R115 T116 R117 K119 G120 R122 R123 R125 R126 L127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8btd, PDBe:8btd, PDBj:8btd
PDBsum8btd
PubMed36912103
UniProtE2RU83

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