Structure of PDB 8brm Chain SQ Binding Site BS01

Receptor Information
>8brm Chain SQ (length=125) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFAVCHIYAGKNDTFIHVTDLSGRETIGRVSGGMKVKRHCDEPSAYAAMQ
ATQDLIEIITDRGITAVHIKIRADGGTGKRVYGQGGSAAIRALVRGGIKI
GRIEDSTPIPTDRTRHKGGRRGRRL
Ligand information
>8brm Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<.........<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<<.............<<.....<<<<<<....>>>>>>..
....>>........<.<.<<<<...[.[...<.....>..>>>>.>>...
.....>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>......>>>>>............<
<<<<<.........>>>>>>.....<<<<<<<......[........((.
.>>))..........].>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<..<<.......
>>...........>>......>>>>>..>.>>>..<<<<<<.....].].
.>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<
..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..
>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<<<......<<........>>........
.<<<<<......<<<<<<.......<<.<<<.......>>>.>>.....>
>>>>>...<<.<<<...<<<<<<<<....<<.<<<<<<....>>>....<
<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<
<<<<....>>>>>........>>>>....>>>.>>>...>.>.>>>>>..
.....>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<.
...>>.>>>.......>>>>>>>......<....<<.<<<<......>>>
>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....
....
Receptor-Ligand Complex Structure
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PDB8brm Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution3.33 Å
Binding residue
(original residue number in PDB)
K37 N38 F41 H43 G49 R50 E51 T52 R55 S57 G59 M60 H65 C66 E68 R88 R98 P134 I135 P136 T137 D138 R139 T140 R141 H142 K143 G145 R146 R147 R149 R150 L151
Binding residue
(residue number reindexed from 1)
K11 N12 F15 H17 G23 R24 E25 T26 R29 S31 G33 M34 H39 C40 E42 R62 R72 P108 I109 P110 T111 D112 R113 T114 R115 H116 K117 G119 R120 R121 R123 R124 L125
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8brm, PDBe:8brm, PDBj:8brm
PDBsum8brm
PubMed36912103
UniProtE2RU83

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