Structure of PDB 8a3w Chain SP Binding Site BS01

Receptor Information
>8a3w Chain SP (length=142) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTKTNGQNAARKLVRLRCRNRWADKGWKRAHTFSARKANPFGGSSHAKGI
VLEKIGVGAKQPNSAIRKCVRVQLIKNDKKIIAFVPNDGCLHFIEENDEV
LVSGFGRSGHAVGDIPGVRFKIVKVSNVGLYALYRQKKEKPR
Ligand information
>8a3w Chain S1 (length=1663) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaau
cagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggcg
aaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccagc
gaaugaaugacaaaaccaaugccgcaguaacacccagcaguguugacuca
auucauuccgugcgaaagccggcuuccggcgucuuuugacgaacaacugc
ccuaucagcuggugauggccguguaguggacugccauggcguugacggga
gcgggggauuaggguucgauuccggagagggagccugagaaauagcuacc
acuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaaa
cgaugaggcagcgaaaagaaauagaguuauuucaaugggggauauuuaaa
cccaucccgagacaauuggaggacaagucuggugccagcacccgcgguaa
uuccagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucgua
guugaacugugggcugcagcccgugaaagaaaaacacgggaggggugcau
gucaugcaugccguccgugauuuuuuacugugacuaaagaagcgugacua
aagcagucaugacuugaauuagaaagcaugggauaacaaaggagcuuuuu
aaagguuggagauuauggagcugugcgacaaaugggaaugaaggagggua
guucgggggagaacguacuggggcgucagaggugaaauucuuagaccgca
ccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaauca
agaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccaca
cugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuu
uacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaaga
gugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugc
gguuuaauuugacucaacacggggaacuuuaccagauccggacagggauu
gacagauugaguguucuuucucgauucccugaaugguggugcauggccgc
uuauggucgguggagugauuuguuugguugauuccgucaacggacgagau
ccaagcugcccaguagaauucagaauuauucggaauucuucucugcggga
uuccuuuguagcacaaggugaaauuuugggcaacagcaggucugugaugc
uccucaauguucugggcgacacgcgcacuacaaugucagugagaacaaga
acuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuu
gggaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguagg
cgcagcucaucaaacugugccgauuacgucccugccauuuguacacaccg
cccgucguuguuuccgaugauggugcaauacaggugaucggacgaaaguu
caccgauauuucuucaauagaggaagcaagucguaacaagguagcuguag
gaccugcagcugg
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<.
....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<<
<<<<<<<<.....((.{..{<<.>>.........................
>>>>>>>>...>>....<<<<<...>>>>>...>>.>>..>>>>..>>>.
<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>.
.<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>
.<<<<....>>>>...>>>>>>.........<<<....<<<.........
.>>>..>>>..>....>>>....<<<....>>>.....<<<<........
....>>>>.......<<<<<((....<.<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...
<<<..<....<........>...........<..............<<<<
.......>>>>.........>...<<<<<<<<.......<<...<.....
..>..<<<..>>>.....>>......>>>>>..>>>..........<<.<
<.<<...}..}.))......>>.>>.>>..........>......<<<<<
..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.
>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>..
.>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>
>>.........<<<.<<...<<<<.<<<<<<.<....>.>>>>>>.>>>>
...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>
>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<
<<<......<<........>>..........<<<<<.<....<<<<....
<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<
<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<
<<<<.<<<<.....<<<<<<<.<<<<.>>>>.>>>>>>>.....>>>>..
..<<<<........>>>>.......>>>>>....>>>.>>>.....>>>>
>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.
..<.<.<..........>.>.>....>........>>>...>>>......
<....<<<..<..........>..>>>.....>.....>>>>>>....<<
<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.....
..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<........>.>
>>>>..>>>>.>.>>>.>>..>>>>>>>>>.>>.........<<<<<<<<
<.>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
Resolution2.89 Å
Binding residue
(original residue number in PDB)		M1 T2 K3 T4 N5 G6 N8 R11 K12 R17 R19 N20 A23 D24 K28 F33 S44 S45 K48 N63 S64 A65 I66 R67 P86 L101 G104 G106 R107 H110 G113 D114 R119 K124
Binding residue
(residue number reindexed from 1)		M1 T2 K3 T4 N5 G6 N8 R11 K12 R17 R19 N20 A23 D24 K28 F33 S44 S45 K48 N63 S64 A65 I66 R67 P86 L101 G104 G106 R107 H110 G113 D114 R119 K124
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum8a3w
PubMed
UniProtQ4QC89

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