Structure of PDB 8k82 Chain SN Binding Site BS01 |
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| >8k82 Chain C2 (length=1771)
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uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuu
ggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcg
uauugcucgaauauauuagcauggaauaauagaauaggacguuugguucu
auuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggg
gcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacu
aacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaa
aguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaac
uaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcacc
uuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggc
ugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcg
gcuuaauuugacucaacacggggaaacucaccagguccagacacaauaag
gauugacagauugagagcucuuucuugauuuugugggugguggugcaugg
ccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacg
agaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuu
cuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacag
gucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacgg
agccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacu
ccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaau
uccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuu
guacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccuca
ggaucugcuuagagaagggggcaacuccaucucagagcggagaauuugga
caaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagg
ugaaccugcggaaggaucauu |
...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<
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......<<<..<<..<<....<<<..................<<....<<
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>>><.<.<<<<<<......(((.{((.<<<....>>>.............
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>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<..............>>>>.>>>>>>....<<<<<<..............
......>>>>>>...<<<<<.<<.......<<...<.......>..<<<<
...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<
<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<
<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>
.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...
.<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.......
...<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>
>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>
>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<
<<......<<........>>..........<<<<<.<....<<<<<....
....<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<
<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>.
...<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>.
.>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>
>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<
<<......<<.....<<..<<<<....>>>>..>>....>>.......>>
>>>>>......<....<<<<<<..........>>>>>>....>.....>>
>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<
...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.
>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<
<..>>>>>>>>>>........ |
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| PDB | 8k82 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. |
| Resolution | 3.0 Å |
Binding residue
(original residue number in PDB) | G2 R3 M4 H5 S6 G8 K9 G10 I11 S12 S13 S14 A15 I16 R20 S48 V52 R55 T61 Q62 R64 K70 M72 R73 Y90 K94 S97 H101 R104 K107 D108 K109 D110 K112 F113 R114 I116 S120 R121 R124 R127 Y128 |
Binding residue
(residue number reindexed from 1) | G1 R2 M3 H4 S5 G7 K8 G9 I10 S11 S12 S13 A14 I15 R19 S47 V51 R54 T60 Q61 R63 K69 M71 R72 Y89 K93 S96 H100 R103 K106 D107 K108 D109 K111 F112 R113 I115 S119 R120 R123 R126 Y127 |
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