Structure of PDB 8fky Chain SN Binding Site BS01

Receptor Information

>8fky Chain SN (length=173) Species: 9606 (Homo sapiens)

TDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVE
RLDVTLGPVPDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAE
MAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQ
QEKAHMMNAIKKYQKGFSDKLDF

Ligand information

>8fky Chain L3 (length=2585)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggag
gauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggug
cgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggc
ucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccg
gggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcac
ggggucggcggcgacgucggcuacccacccgacccgucuugaaacacgga
ccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccg
uggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgu
cucgcccggggagguggagcacgagcgcacguguuaggacccgaaagaug
gugaacuaugcaagccagaggaaacucugguggguauaggggcgaaagac
uaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcu
cucgcgcaguuuuauccgguggguaagaagcccggcucgagccgggcgug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuug
aagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggu
gguaguagcuucaaacgagaacuuugaaggccgaaguggagaaggguucc
auguacaugggucagucgguccuagggacgggcgauggccuccggcccgc
cggggagucggguucagauccccgaauccggaguggcggagaugggcgcc
gcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcggga
gccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaau
ggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccg
gcggcguccggugagcucucgcuggcaauccgggggagaggguguaaauc
ucgcgccgggccguacccuccaaggugaacagccucuggcaauguaggua
agggaagucgggaauccgauucccacugucccuaccuacuauccagcgaa
accacagccaagggaacgggcuuggcggaaucagcggggagaagacccug
uugagcuugacucuagucuggcacggugaagagacaugagagguguagaa
uaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuc
cagugccagguggggaguuauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgc
gacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaau
ucaccaagcguuggauuguucacccacuaauagggaacgugagcugggga
ccgucgugagacagguuagucccuacugaugguuguugccaugguaaucc
ugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcu
gaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgcc
ucuaagucagaaucccgcccaggcggaacgauacagcgccgcggagccuc
gguuggccucggauagccgguccccgggguccggugcggagugcccuucg
uccugggaaacggggcgcggccggagaggcggccgcccccucgcccguca
cgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgacc
ugcuucugggucgggguuucguacguagcagagcagcucccucgcugcga
ucuauugaaagucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
.....................<<<<<<<<..<<<.<<...<<<<<<<<.<
<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..
.<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<
<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>
>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>..
....>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><
<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>....
.>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<
<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<
<<...<<<<<...<<<<<<<....>>>>>>>...>>>>><<.<....>.>
>.>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<
<....<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>...
.>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.......
..>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<
<<<..>>>>>....((<<<<<...<<...<<<<...........>>>>.>
>..>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<
....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<
<..<<<<<<<<<<.......>>>>>>.....<<<<.<<<<.<<<<.....
<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......
>>>>>>>>>>>....>>>>>>>>>>>..>>>>>>>.............>>
.>>>.>>>>>>>>..>>>>>>.<<<<.....>>>>..>>>...<<<<<<.
<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>...
.>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<
<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<........
..<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>
..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>
>>........>>>>>.>.>>>>>>.............<<<<<<...<..>
...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>
>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<
<<<<<....>>>.>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<
<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<
....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<.......
....>>>>>...>>>>>.>>>...>.>>>>>>..<<<<<<<.<<..<<<<
....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<
<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>
>>..............>>>>..>>>>>>>>><<<<<.<............
.>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fky Principles of human pre-60 S biogenesis.
• Resolution: 2.67 Å
• Binding residue (original residue number in PDB): K153 K157 K166 Q169 R171 L173 R174 K178 Q181 R188 Q189
• Binding residue (residue number reindexed from 1): K114 K118 K127 Q130 R132 L134 R135 K139 Q142 R149 Q150

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005730 nucleolus
• GO:0030687 preribosome, large subunit precursor
• GO:0034399 nuclear periphery

External links

• PDB: RCSB:8fky, PDBe:8fky, PDBj:8fky
• PDBsum: 8fky
• PubMed: 37410842
• UniProt: Q99848|EBP2_HUMAN Probable rRNA-processing protein EBP2 (Gene Name=EBNA1BP2)