Structure of PDB 8fla Chain SM Binding Site BS01

Receptor Information
>8fla Chain SM (length=399) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHK
KKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEW
NTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTG
KCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVW
ITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLE
GQGTYALDSESCMEKLAALSASLARVVVSAQEEDRRKELEAQEKHKKLFE
GLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIV
DRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFV
Ligand information
>8fla Chain L1 (length=154) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgu
cgcu
.........................................<<<<<<.<<
.....>>>.....(.<<<......>>.............>>>..)...>>
>....<<....>><<<<<<<<<...>>>>>>>>>................
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fla Principles of human pre-60 S biogenesis.
Resolution2.63 Å
Binding residue
(original residue number in PDB)		R11 G12 S13 N16 K26 R71 H75 K86 V87 R90
Binding residue
(residue number reindexed from 1)		R10 G11 S12 N15 K25 R70 H74 K85 V86 R89
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0008283 cell population proliferation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fla, PDBe:8fla, PDBj:8fla
PDBsum8fla
PubMed37410842
UniProtO00541|PESC_HUMAN Pescadillo homolog (Gene Name=PES1)

[Back to BioLiP]