Structure of PDB 8fkt Chain SM Binding Site BS01

Receptor Information
>8fkt Chain SM (length=453) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAAR
TFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKP
NYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCR
RLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHP
TDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQGTYALDSES
CMEKLAALSASLARVVVSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVP
REALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIG
RCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEK
LKLLALQRGREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAK
KAR
Ligand information
>8fkt Chain L1 (length=152) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcua
gcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucg
aacgcacuugcggccccggguucccggggcuacgccugucugagcgucgc
uu
.......................................<<<<<<<<<..
..>>>>.....<.<<<......>>.............>>>..>...>>>.
...<<....>><<<<<<<<<..>>>>>>>>>...................
..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fkt Principles of human pre-60 S biogenesis.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		N16 K26 R71 H75 R90
Binding residue
(residue number reindexed from 1)		N4 K14 R59 H63 R78
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0008283 cell population proliferation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fkt, PDBe:8fkt, PDBj:8fkt
PDBsum8fkt
PubMed37410842
UniProtO00541|PESC_HUMAN Pescadillo homolog (Gene Name=PES1)

[Back to BioLiP]