Structure of PDB 8hl1 Chain SL7A Binding Site BS01

Receptor Information

>8hl1 Chain SL7A (length=123) Species: 330779 (Sulfolobus acidocaldarius DSM 639)

PSYVKFEVPQELADKVLEAVKKAKDSGKIKKGTNETTKAVERSQAKLVVI
AEDVQPEEIVAHLPLLCEEKKIPYVYVPSKKSLGEACGLQVAAASVALMD
PGEAKDLVDEIVKRVNEIKGKSS

Ligand information

>8hl1 Chain A16S (length=1493)

auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc
augggagucuuacacucccggguaagggaguguggcggacggcugaguaa
cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga
uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu
auaggcuauuucccguuuguagccgcccgaggauggggcuacggcccauc
aggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccg
uggaagcgggagccuccaguugggcacugagacaagggcccaggcccuac
ggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgc
uaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggg
gaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuc
cgcgaguggucggggugauuacugggccuaaagcgccuguagccggccca
ccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgaua
cuggugggcuagggggcgggagaggcgggggguacucccggaguaggggc
gaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuag
aacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuaga
uaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggc
uuagagccuacucggugccgcagggaagccguuaagcccgccgccugggg
aguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccaca
agggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgg
gggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcgga
gaggaggugcauggccgucgccagcucguguugugaaauguccgguuaag
uccggcaacgagcgagacccccaccccuaguugguauucuggacuccggu
ccagaaccacacuagggggacugccggcguaagccggaggaaggaggggg
ccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuaca
auggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaa
cccugccgcaguugggaucgagggcugaaacccgcccucgugaacgagga
aucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcucc
uugcacacaccgcccgucgcuccacccgagcgagaaaggggugagguccc
uugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucg
uaacaagguagccguaggggaaccugcggcuggaucaccucau

...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<
.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<......
..<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.
>...>>>>>..<<<<<<<<<<.<<......>>>>>>>>>>>>...<<.<<
<<<<............>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<...
.<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<
<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..
>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>
>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>
>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>
>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<
<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..
>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<..<.<<<..
....>>>......>>>>>>>>..>>.......<<....>>.>>>>>>>..
..>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<....
.>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<
.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.
.....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.
<<<<<<..<<<<<<<<.<......<<........>>..........<<<<
<.<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>.
..<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<.....
.>>>>..>>>>>>....<<<<<.<<<<<<<.<.....<<<<<<<....>>
>>>>>.....>>>>>>>>.....<<<<<....>>>>>........>>>>>
.....>>.>>>...>>>>>>>>.....>>>>>>...>..>>>>>>>>...
..<<<<<<<.....<<...<<..<<<......>>>..>>....>>.....
>>>>>>>......<....<<<<<<<........>>>>>>>....>.....
>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>
>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<
<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>
...>.....<<<<<<<<<....>>>>>>>>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hl1 Cryo-electron microscopy structure and translocation mechanism of the crenarchaeal ribosome.
• Resolution: 3.93 Å
• Binding residue (original residue number in PDB): Y6 K34 G35 T36 V57 Q58 P59 E60 E61 I62 V63 V94 A95 A97
• Binding residue (residue number reindexed from 1): Y3 K31 G32 T33 V54 Q55 P56 E57 E58 I59 V60 V91 A92 A94

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0004526 ribonuclease P activity
• GO:0019843 rRNA binding

Biological Process

• GO:0001682 tRNA 5'-leader removal
• GO:0006412 translation
• GO:0008033 tRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8hl1, PDBe:8hl1, PDBj:8hl1
• PDBsum: 8hl1
• PubMed: 37604686
• UniProt: Q4J8P1|RL7A_SULAC Large ribosomal subunit protein eL8 (Gene Name=rpl7ae)