Structure of PDB 8y0x Chain SL Binding Site BS01

Receptor Information
>8y0x Chain SL (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADIQTERAYQKQPTIFQNKKRVLLKLPRYYKNIGLGFKTPKEAIEGTYID
KKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHK
NMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQ
Ligand information
>8y0x Chain S2 (length=1739) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggcc
gaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuau
caacuuucgaugguagucgccgugccuaccauggugaccacgggugacgg
ggaaucaggguucgauuccggagagggagccugagaaacggcuaccacau
ccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggaggu
agugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaa
ugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucugg
ugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcu
gcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccuc
ucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagc
aggcccgagccgccuggauaccgcagcuaggaauaauggaauagaccgcg
guucuauuuuguugguuuucggaacugaggccaugauuaagagggacggc
cgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgca
agacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaaga
acgaaagucggagguucgaagacgaucagauaccgucguaguuccgacca
uaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgg
gcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugc
aaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagc
cugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacg
gacaggauugacagauugauagcucuuucucgauuccgugggugguggug
cauggccguucuuaguugguggagcgauuugucugguuaauuccgauaac
gaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggc
gucccccaacuucuuagagggacaaguggcguucagccacccgagauuga
gcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcu
acacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaa
cccguugaaccccauucgugauggggaucggggauugcaauuauucccca
ugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaag
ucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuu
agugaggcccucggaucggccccgccggggucggcccacggcccuggcgg
agcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgu
aacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..................<<.....
<<.<<<.....>>>.>>......>>.........<<<<...<<<<.....
...>>>>...>>>><<..<<<<<...<......>..>>>>>......>>.
..<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<..
..<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<
.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<
<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>
..>...>>.>.....<<.....<<..<<....>>..>>.......>>...
...<<..<...........>..>>.........<<<<<((....<.<<<<
.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>........
.<.<((.....<.<<...<<<.<<.......................<<.
<.............>>>...<<<<<<.<.......<<...<.......>.
<<<<.......>>>>...>>......>.>>>..>>>.......<.<<.<<
<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..
<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>
>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>
.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..
........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.
>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<..
..>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<
.<<<<<<......<<........>>..........<<<<<.<....<<<<
<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.
.<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>
.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>
>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>
>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>
.....<<.<<<........<.......<<<.<<<<....>>>>.>>>...
.>.........>>>.>>............<<<<<..........>>>>>.
..........>>>>>.....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.
<<<..<<<<.<<...<<<<<...<<.....................>>..
...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.
..>.....<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8y0x The global structure of dormant ribosome
Resolution3.3 Å
Binding residue
(original residue number in PDB)		E7 R8 A9 Q11 T15 F17 Y36 N39 G41 L42 K58 K59 N65 S67 I68 R69 R71 K79 K81 M82 Q83 Y92 H94 K98 K104 R105 H106 K107 N108 E130 R132 P133 L134 S135 K136 T137 R139 F140
Binding residue
(residue number reindexed from 1)		E6 R7 A8 Q10 T14 F16 Y29 N32 G34 L35 K51 K52 N58 S60 I61 R62 R64 K72 K74 M75 Q76 Y85 H87 K91 K97 R98 H99 K100 N101 E123 R125 P126 L127 S128 K129 T130 R132 F133
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8y0x, PDBe:8y0x, PDBj:8y0x
PDBsum8y0x
PubMed38698775
UniProtP62280|RS11_HUMAN Small ribosomal subunit protein uS17 (Gene Name=RPS11)

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