Structure of PDB 8ovj Chain SL Binding Site BS01

Receptor Information
>8ovj Chain SL (length=143) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YALKQVQTFGKKKTAIAVATVTKAAQCNIKVNGVPLQQILPDTLRAKIME
AITVVGSKYYSRLRIDVAVHGGGQVSQAYAARQAIAKGLIAFFQKYHNEV
EKAALKDKFLAYDKFLLIADPRRCEPKKWGRHSARTRFTKSYR
Ligand information
>8ovj Chain S1 (length=1755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggc
gaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccag
cgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguuga
cucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacug
cccuaucagcuggugauggccguguaguggacugccauggcguugacggg
agcgggggauuaggguucgauuccggagagggagccugagaaauagcuac
cacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaa
acgaugaggcagcgaaaagaaauagaguuuuucaaugggggauauuuaaa
cccauccaauaucgaguaacaauuggaggacaagucuggugccagcaccc
gcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaagg
guucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacac
gggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacu
aaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggaua
acaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugc
uuucccaucucggugugggguuuacggccucuaggaaugaaggaggguag
uucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcac
caagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaa
gaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacac
ugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuu
uuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaag
agugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgug
cgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaug
aggauugacagauugaguguucuuucucgauucccugaaugguggugcau
ggccgcuuauggucgguggagugauuuguuugguugauuccgucaacgga
cgagauccaagcugcccaguagaauucagaauugcccauaggauagcgca
uucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaacuacuugaucaaaagaguggggaaacc
ccggaaucacauagacccacuugggaccgaggauugcaauuauuggucgc
gcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacg
ucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaa
uacaggugaucggacagggcccgaaaguucaccgauauuucuucaauaga
ggaagcaaaagucguaacaagguagcuguaggggaaccugcagcugggac
auuuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<
.....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<
<<<<<<<<<.....((.((.{..{<<.>>.....................
....>>>>>>>>>>....<<<<<...>>>>>...>>.>>..>>>>..>>>
.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>
..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>
>.<<<<<..>>>>>...>>>>>>.........<<<....<<<........
..>>>..>>>..>....>>>....<<<...>>>.....<<<<........
....>>>.....>.........<<<<<((....<.<<<<.....<<..))
>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....
<<<<...<<<.......<.............>............<.....
...........<<<<.......>>>>.........>...<<<<<<<<...
....<<...<.......>..<<<..>>>.....>>......>>>>>..>>
>..........<<.<<.<<...}..}.)).))...>>.>>.>>.......
.......<...<.<....>.>....>..................<<<<<.
.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>
>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...
>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
>.........<<<.<<.<.<...<<<<<<...........>>>>>>...>
.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<
<<<<......<<........>>..........<<<<<.<....<<<<...
......<<.<<<........>>>.>>.......>>>>.<.<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<<<.....<<<<<<<.<<<<.................>
>>>.>>>>>>>.....>>>>....<<<<........>>>>.......>>>
>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<..<<.<.<..........>.>.>>...>.
.......>>>...>>>......<....<<<..<..........>..>>>.
....>.....>>>>>>....<<<<<<<.........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<
<<..<<<<<.<...<.<...>.>...>.>>>>>..>>>>.>.>>>.>>..
>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.....
Receptor-Ligand Complex Structure
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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)
Y7 Q11 Q13 K19 T20 A30 C33 I35 K36 L42 Q43 S67 G77 G78 G79 V81 S82 Q83 R128 R129 C130 E131 P132 K133 K134 W135 R137 S139 R141 T142 R143 T145 K146 S147
Binding residue
(residue number reindexed from 1)
Y1 Q5 Q7 K13 T14 A24 C27 I29 K30 L36 Q37 S61 G71 G72 G73 V75 S76 Q77 R122 R123 C124 E125 P126 K127 K128 W129 R131 S133 R135 T136 R137 T139 K140 S141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4Q9A5

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