Structure of PDB 7mqa Chain SL Binding Site BS01

Receptor Information

>7mqa Chain SL (length=175) Species: 9606 (Homo sapiens)

GKQKKTRKYATMKRMDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDT
NFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRI
AKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPG
VPIMYISNHRYNIERMPDDYGAPRF

Ligand information

>7mqa Chain L1 (length=1636)

accugguugauccugccaguagcauaugcuugucucaaagauuaagccau
gcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauu
aaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccggggggaug
cgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcg
gcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcg
gcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgcc
gugccuaccauggugaccacgggugacggggaaucaggguucgauuccgg
agagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcg
caaauuacccacucccgacccggggagguagugacgaaaaauaacaauac
aggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuu
aacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuc
caauagcguauauuaaacugcaguuaaaaagcucguaguuggaucuuggg
agcgggcgggcgguccagccaccgcccguccccgccccuugccucucggc
gccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcc
ccgccuggauaccgcagcuaggaauaauggggaccgcgguucuaggaacu
gaggccaugauuaagagggacggccgggggcauucguauugcgccgcuag
aggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugc
caagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgau
cagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggc
ggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuu
ggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacg
gaagggcaccaccaggaguggagccugcggcacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccguggguuggugcaugg
ccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucu
ggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccguccggggcacgcgcgcuacacugacuggcucag
cguguguacgccggcaggcgcgaaccccauucgugauggggaucggggau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuucacaccgcccgucgcuacuaccgauugga
ugguuuagugaggcccucggaucggccccgccggggucggcccacggccc
uggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaa
aguuccguaggugaaccugcggaaggaucauuaacg

..<<<<<.......>>>>>.<<.<<<<<<...<.<<.........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<.<....<<....<<<................<<.....<<.<<
.......>>.>>......>>.........<<<<...<<<<..>>>>...>
>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>
..>>...........>>>>>......>>...<<<<.<<<<......>>>>
>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.....
....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.
>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>...
......<<<....<<<.....>>>..>>>......>>.>.....<<<<<<
<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>.
.>>.........<<<<<<.......<<<....>>>............>>>
>>>..>>>>>>.>>......<.<((.....<.<<...<<<.<<<<<.<<<
.<<<<<<<<<<<<<......>>>>>>>>>..>>>>>>>.<<<...<<<<.
<<..>>>>>>.>>>.<<<<<<.<.......<<..<<.......>>.<<<.
..>>>....>>......>.>>>..>>>.>><<.<<.<<<<<<<.>>>>>>
>.>>>>...>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<
<<......>>>......>>>>>>>>..>>.......<<....>>...>>>
>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..
.......>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<
<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>....
.>>>.>.>......................................<<<<
<<<<<<<<..<<..<<<<<..<<<.<<<<<<.<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>....<<<.<<<<<
<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<.
..<...<..>..>.....<<<<<.....>>>>>........>>>....>>
>.>>.>>>>>..>>>...>>>>>>>.>>>>.>>>.....<<.<<<.....
........<<<<....>>>>......>>>.>>......<.....<<<<<.
<>.>>>>>.....>.....>>>>>.....<<<<<<<.........>>>>>
>>......>>...>>>>>>>.........>>>>>..<<<<.<<..<.<<<
<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>
>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>..
..<<<<<<<<<....>>>>>>>>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): G2 K3 Q4 K5 R46 N77 F78 K81 K83 K116 Y117 A120 D161 R162 K165 R166 N181 H182 R183 F198
• Binding residue (residue number reindexed from 1): G1 K2 Q3 K4 R23 N54 F55 K58 K60 K93 Y94 A97 D138 R139 K142 R143 N158 H159 R160 F175

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q9Y324|FCF1_HUMAN rRNA-processing protein FCF1 homolog (Gene Name=FCF1)