Structure of PDB 8y0w Chain SK Binding Site BS01

Receptor Information
>8y0w Chain SK (length=98) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQ
SLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSR
Ligand information
>8y0w Chain S2 (length=1735) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggcc
gaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuau
caacuuucgaugguagucgccgugccuaccauggugaccacgggugacgg
ggaaucaggguucgauuccggagagggagccugagaaacggcuaccacau
ccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggaggu
agugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaa
ugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucugg
ugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcu
gcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccuc
ucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagc
aggcccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguuc
uauuuuguugguuuucggaacugaggccaugauuaagagggacggccggg
ggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagac
ggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacga
aagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaa
cgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcag
cuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaag
cugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugc
ggcuuaauuugacucaacacgggaaaccucacccggcccggacacggaca
ggauugacagauugauagcucuuucucgauuccgugggugguggugcaug
gccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaac
gagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucc
cccaacuucuuagagggacaaguggcguucagccacccgagauugagcaa
uaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacac
ugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccg
uugaaccccauucgugauggggaucggggauugcaauuauuccccaugaa
cgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggucggcccacggcccuggcggagcg
cugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaaca
agguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..................<<.....
<<.<<<.....>>>.>>......>>.........<<<<...<<<<.....
...>>>>...>>>><<..<<<<<...<......>..>>>>>......>>.
..<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<..
..<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<
.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<
<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>
..>...>>.>.....<<.....<<..<<....>>..>>.......>>...
...<<..<...........>..>>.........<<<<<((....<.<<<<
.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>........
.<.<((.....<.<<...<<<.<<.......................<<.
<.............>>>...<<<<<<.<.......<<...<.......>.
<<<<..>>>>...>>......>.>>>..>>>........<.<<.<<<.<<
<...............>>>.>>>.>>.>....>>....<<<<<<..<...
<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>
>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>..
..<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>......
....<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>
>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>
>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<
<<<......<<........>>..........<<<<<......<<<<<<..
.....<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.
<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>
....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..
...>>>>..>>>>..>.....<<<<<.....>>>>>........>>>...
.>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>....
.<<.<<<........<.......<<<.<<<<....>>>>.>>>....>..
.......>>>.>>......<...<.<<<<<..........>>>>>>....
>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<.<<<<<<.<<<.
.<<<<.<<...<<<<<...<<.....................>>.....>
>>>>...>>.>>>>..>>>.>>>>>>.>...>>.>>>>...>.>>...>.
....<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8y0w dormant ribosome with eIF5A, eEF2 and SERBP1
Resolution3.4 Å
Binding residue
(original residue number in PDB)		M1 L2 M3 K5 L43 K47 Q50 S51 S54 R55 F62
Binding residue
(residue number reindexed from 1)		M1 L2 M3 K5 L43 K47 Q50 S51 S54 R55 F62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8y0w, PDBe:8y0w, PDBj:8y0w
PDBsum8y0w
PubMed38698775
UniProtP46783|RS10_HUMAN Small ribosomal subunit protein eS10 (Gene Name=RPS10)

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