Structure of PDB 8g60 Chain SK Binding Site BS01

Receptor Information
>8g60 Chain SK (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQ
SLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR
Ligand information
>8g60 Chain S2 (length=1654) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucccacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccgggggaugcgugcau
uuaucaguggugacucuagauaaccucgggccgaucgcacgccccccgug
gcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguaguc
gccgugccuaccauggugaccacgggugacggggaaucaggguucgauuc
cggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggc
gcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaa
uacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaaucc
uuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaa
uuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgua
guuggaucuuguuacuuugaaaaaauuagaguguucaaagcaggcccgag
ccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauu
uuguugguuuucggaacugaggccaugauuaagagggacggccgggggca
uucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggac
cagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagu
cggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgau
gccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuc
cgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcuga
aacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcu
uaauuugacucaacacgggaaaccucacccggcccggacacggacaggau
ugacagauugauagcucuuucucgauuccgugggugguggugcauggccg
uucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgaga
cucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccccca
acuucuuagagggacaaguggcguucagccacccgagauugagcaauaac
aggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugac
uggcucagcgugugccuacccuacgccggcaggcgcggguaacccguuga
accccauucgugauggggaucggggauugcaauuauuccccaugaacgag
gaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcc
cuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggc
ccucggaucggcccgagcgcugagaagacggucgaacuugacuaucuaga
ggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggauc
auua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<....
...>>.>>......>>.........<<<<...<<...>>...>>>><<..
<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>
>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<..
.......>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>
>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>
.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<
<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<..........
.>..>>.........<<<<<((....<.<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...
<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.....
..>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...
............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<
..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>...
....<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<
<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........
<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>..
.<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>..
..>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<..
.....<<........>>..........<<<<<.<....<<<<<<......
.<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<
<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....
<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>
>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>
.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<.
<<<........<.......<<<.<<<<....>>>>.>>>....>......
...>>>.>>......<.....<<<<<..........>>>>>.....>...
..>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>
>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<
<.<<...<<<<<......>>>>>...>>.>>>>..>>>.>>>>>>>>...
>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g60 mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		M1 M3 K5 K25 L43 K47 Q50 S51 S54 E60 F62 F67
Binding residue
(residue number reindexed from 1)		M1 M3 K5 K25 L43 K47 Q50 S51 S54 E60 F62 F67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g60, PDBe:8g60, PDBj:8g60
PDBsum8g60
PubMed37020024
UniProtP46783|RS10_HUMAN Small ribosomal subunit protein eS10 (Gene Name=RPS10)

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