Structure of PDB 8rxh Chain SJ Binding Site BS01

Receptor Information
>8rxh Chain SJ (length=129) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMMSVLANALRTIASAERRGKRQVLIRPSSKVVVKFLQVMQKHGYIGEFE
IIDDHRAGKIVVNLNGRLNKCGAICPRFDCATTDYEKWMKNILPSRQFGF
VVLTTSLGIMDHEEARSRNTGGKVLGFFY
Ligand information
>8rxh Chain S1 (length=1844) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuu
ggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugag
acgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacaccca
gcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcguc
uuuugacgaacaacugcccuaucagcuggugauggccguguaguggacug
ccauggcguugacgggagcgggggauuaggguucgauuccggagagggag
ccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugc
ccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagaguuguuug
ucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauugg
aggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcgua
uauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugc
agggcccuugcagcccgugaaaaagaaacaagaaacacgggagugggucg
caugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaa
gcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaa
aggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucu
auuggagauuauggagcuguuucccacggugugacggccucuaggaauga
aggaggguaguucgggggagaacguacuggggcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauug
uaguccacacugcaaacgaugacacccaugaauuggggauacuuaguauc
uuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucu
caggggggaguacguucgcaagagugaaacuuaaagaaauugacggaaug
gcaccacaagacguggagcgugcgguuuaauuugacucaacacggggaac
uuuaccagauccggacaggaugagauugacagauugaguguucuuucucg
auucccugaaugguggugcauggccgcuuauggucgguggagugauuugu
uugguugauuccgucaacggacgagauccaagcugcccaguagaauucag
aauugcccauaggauagcgcauucggucgaauucuucucugcgggauucc
uuuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcu
ccucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaa
aaacgaucgaaccuacuugaucaaaagaguggggaaaccccggaaucaca
uagacccacuugggaccgaggauugcaauuauuggucgcgcaacgaggaa
ugucucguaggcgcagcucaucaaacugugccgauuacgucccugccauu
uguacacaccgcccgucguuguuuccgaugauggugcaauacaggugauc
ggacaggcgcccgaaaguucaccgauauuucuucaauagaggaagcaaaa
gucguaacaagguagcuguaggggaaccugcagcugggacauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
.<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<
<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>
>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>...........
..............>>>>>>>>...>>....<<<<<......>>>>>...
>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>
>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<
<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<
<....<<<..........>>>..>>>..>....>>>....<<<.<<....
.>>.>>>.....<<<<............>>>.....>.........<<<<
<<<........((.....((..>>)).......))...>>>>>..>>>>>
>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<.
.<..>.>.>>...>...................<...............<
<<<.......>>>>.............>.....<<<<<<<<.......<<
...<.......>..<<<....>>>.....>>......>>>>>..>>>...
........<<..<<<<<<.<<<...>>>.....)))).)))))..>>>>>
>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>........
....<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>.
.....>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<.
.........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.
>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<
<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>......
....<<<<<.<....<<<<........<<.<<<........>>>.>>...
....>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>..
.<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<
<<<.................>>>>....>>>>>>>.....>>>>....<<
<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>
>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<..
...<<..>>..<<<<<<<........>>>>>>>....>........>>>.
..>>>......<....<<<..<..........>..>>>.....>.....>
>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>
>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<
...<.<....>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..
>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		T2 M3 M4 V6 N9 R12 R19 R20 R28 S31 K32 R57 A58 K60 N70 K71 A74 I75 C76 R78 D80 A82 T83 K91 T105 T106 S107 N120 G122 Y130
Binding residue
(residue number reindexed from 1)		T1 M2 M3 V5 N8 R11 R18 R19 R27 S30 K31 R56 A57 K59 N69 K70 A73 I74 C75 R77 D79 A81 T82 K90 T104 T105 S106 N119 G121 Y129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4QGW3

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