Structure of PDB 8fkz Chain SI Binding Site BS01

Receptor Information

>8fkz Chain SI (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LVPENLLKKRKAYQALKATQAKQALLAKKEQKKGRFKRLESFLHDSWRQK
RDKVRLRRLEVKPHALELPDKHSLAFVVRIERIDGVSLLVQRTIARLRLK
KIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNK
TIPLTDNTVIEEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSV
ARHATKNRVGFLKEMGTPGYRGERINQLIRQLN

Ligand information

>8fkz Chain L2 (length=68) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccucc
gucccccuaagcgcagac

.........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.>
>.>>>>>...........

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fkz Principles of human pre-60 S biogenesis.
Resolution	3.04 Å
Binding residue (original residue number in PDB)	L65 H66 W69 K72 R80 P85 H86 R230
Binding residue (residue number reindexed from 1)	L43 H44 W47 K50 R58 P63 H64 R208

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001825	blastocyst formation

	Cellular Component
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8fkz, PDBe:8fkz, PDBj:8fkz
PDBsum	8fkz
PubMed	37410842
UniProt	Q6DKI1\|RL7L_HUMAN Ribosomal protein uL30-like (Gene Name=RPL7L1)

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