Structure of PDB 8fkt Chain SI Binding Site BS01

Receptor Information

>8fkt Chain SI (length=228) Species: 9606 (Homo sapiens)

IPLVPENLLKKRKAYQALKATQAKQALLARFKRLESFLHDSWRQKRDKVR
LRRLEVKPHALELPDKHSLAFVVRIERIDGVSLLVQRTIARLRLKKIFSG
VFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLT
DNTVIEEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSVARHAT
KNRVGFLKEMGTPGYRGERINQLIRQLN

Ligand information

>8fkt Chain L1 (length=152)

acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcua
gcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucg
aacgcacuugcggccccggguucccggggcuacgccugucugagcgucgc
uu

.......................................<<<<<<<<<..
..>>>>.....<.<<<......>>.............>>>..>...>>>.
...<<....>><<<<<<<<<..>>>>>>>>>...................
..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkt Principles of human pre-60 S biogenesis.
• Resolution: 2.81 Å
• Binding residue (original residue number in PDB): R57 F58 S63
• Binding residue (residue number reindexed from 1): R30 F31 S36

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0001825 blastocyst formation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fkt, PDBe:8fkt, PDBj:8fkt
• PDBsum: 8fkt
• PubMed: 37410842
• UniProt: Q6DKI1|RL7L_HUMAN Ribosomal protein uL30-like (Gene Name=RPL7L1)