Structure of PDB 8fkp Chain SI Binding Site BS01

Receptor Information

>8fkp Chain SI (length=199) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RFKRLESFLHDSWRQKRDKVRLRRLEVKPHALELPDKHSLAFVVRIERID
GVSLLVQRTIARLRLKKIFSGVFVKVTPQNLKMLRIVEPYVTWGFPNLKS
VRELILKRGQAKVKNKTIPLTDNTVIEEHLGKFGVICLEDLIHEIAFPGK
HFQEISWFLCPFHLSVARHATKNRVGFLKEMGTPGYRGERINQLIRQLN

Ligand information

>8fkp Chain L2 (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccuc
cgucccccuaagcgcagac

..........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.
>>.>>>>>...........

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fkp Principles of human pre-60S biogenesis
Resolution	2.85 Å
Binding residue (original residue number in PDB)	L65 H66 W69 R70 K72 R73 V76 R80 K84 P85 H86 R104 K228 R230
Binding residue (residue number reindexed from 1)	L9 H10 W13 R14 K16 R17 V20 R24 K28 P29 H30 R48 K172 R174

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001825	blastocyst formation

	Cellular Component
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:8fkp, PDBe:8fkp, PDBj:8fkp
PDBsum	8fkp
PubMed	37410842
UniProt	Q6DKI1\|RL7L_HUMAN Ribosomal protein uL30-like (Gene Name=RPL7L1)

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