Structure of PDB 8tpu Chain SH Binding Site BS01

Receptor Information
>8tpu Chain SH (length=204) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISNPLNNVQKSIEIDDEKKLLPFMEKRIGNAVPGDSIGEEFTGYVF
RITGGNDKQGFPMIQGVLTNNRVRLLFKKGMKCYRPRKKGERKRKSVRGC
IVGQDLSALNLTLVKKGVNEIPGLTDKAVGKKLGPKRASKIRKLFNLDKS
DDVRKYVIGRFIKPKIQRLVTEKRLLRKRNLLQAKEKRRLEKKQQLKEYK
QLLN
Ligand information
>8tpu Chain SA (length=1608) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagcc
augcaagugaaaguauauauauauauauguagaaacugcgaacggcucau
uaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagc
uguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaa
uuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugacc
uaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaa
cggggaauuagaguucgauuccggagagggagccugagaaauagcuacca
caucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagaga
gguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaau
uuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagc
cgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaa
cgcucguaguugaauuucaaagaaucauucuuuuuaaaauccgauuuugu
uacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguu
ugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuugu
ucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucgu
auucagaugucagaggugaaauucuuagauuuucuggagacgaacaacug
cgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagg
gagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccga
cuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagu
cuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauu
gacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaac
acggggaaacucacuaguuuaagacauuggauggugaugcauggccguuu
uuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuu
aaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaa
cauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugaug
uccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgag
uaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuu
aucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaa
cgaggaaugccuaguaagcaugauucaucagauugugcugacuacguccc
ugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaug
aauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucu
uuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcgga
aggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<...
.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>
>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<.....
.>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<
<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..
>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.
........>>>>>>.........<<<<<((......<<<<.....<<..)
)>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((....
.<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<.>>.>>><<
<<<<.<<.......<<...<.......>..<<<.......<<...>>>>>
....>>......>>.>>..>>>>.....<<<<<.<<...<<<.<......
....>.>>>...>>.>>>.>>.>>....<<<<<<..<<..<<<<<..<<<
.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<
<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<.
..<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<
<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>
.....>>>.>>>.<<<.....<<<<<....>>>>>...>>>..)))).]<
<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<<<....<<.>>...<<.<<<..<<.<<<<<<.
...<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<
<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>..
..<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>
>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<......<<
...<.<<<<<..>>>>>.>...<<<.<<<<....>>>>.>>>....>>..
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<.
.<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>
>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>
>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tpu Divergent translational landscape reflects adaptation to biased codon usage in malaria parasites
Resolution4.1 Å
Binding residue
(original residue number in PDB)
K2 N4 S6 N11 Q13 S15 R31 R51 T53 N56 Q59 Q65 G66 V67 L68 R72 C83 Y84 R85 R87 K88 K89 G90 E91 R92 R94 K95 S96 N110 K115 K131 L133 G134 K136 R137 S139 K140 R154 K155 F170 K172 P173 R177 V179 R183 L184 R186 K187 K194 R197
Binding residue
(residue number reindexed from 1)
K2 N4 S6 N11 Q13 S15 R31 R51 T53 N56 Q59 Q65 G66 V67 L68 R72 C83 Y84 R85 R87 K88 K89 G90 E91 R92 R94 K95 S96 N110 K115 K131 L133 G134 K136 R137 S139 K140 R154 K155 F161 K163 P164 R168 V170 R174 L175 R177 K178 K185 R188
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