Structure of PDB 8ovj Chain SH Binding Site BS01

Receptor Information
>8ovj Chain SH (length=182) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSKTPKLFNKWSFEGLETSELALRDHISTTAAYVPHTSGRWQKRRFYKAR
MPIVERLANGLMFKGRGNGRKLQAARLLKHTLEIIHLLTDENPLQVVVDA
VSKGAPREDSTRRRQAVDVSPMRRVNEAIYQMCKGAREAAFRNLKSMPEC
LADEIVNASKGSSNSYAIKKKDEVERVAKANR
Ligand information
>8ovj Chain S1 (length=1755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggc
gaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccag
cgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguuga
cucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacug
cccuaucagcuggugauggccguguaguggacugccauggcguugacggg
agcgggggauuaggguucgauuccggagagggagccugagaaauagcuac
cacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaa
acgaugaggcagcgaaaagaaauagaguuuuucaaugggggauauuuaaa
cccauccaauaucgaguaacaauuggaggacaagucuggugccagcaccc
gcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaagg
guucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacac
gggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacu
aaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggaua
acaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugc
uuucccaucucggugugggguuuacggccucuaggaaugaaggaggguag
uucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcac
caagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaa
gaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacac
ugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuu
uuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaag
agugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgug
cgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaug
aggauugacagauugaguguucuuucucgauucccugaaugguggugcau
ggccgcuuauggucgguggagugauuuguuugguugauuccgucaacgga
cgagauccaagcugcccaguagaauucagaauugcccauaggauagcgca
uucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaacuacuugaucaaaagaguggggaaacc
ccggaaucacauagacccacuugggaccgaggauugcaauuauuggucgc
gcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacg
ucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaa
uacaggugaucggacagggcccgaaaguucaccgauauuucuucaauaga
ggaagcaaaagucguaacaagguagcuguaggggaaccugcagcugggac
auuuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<
.....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<
<<<<<<<<<.....((.((.{..{<<.>>.....................
....>>>>>>>>>>....<<<<<...>>>>>...>>.>>..>>>>..>>>
.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>
..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>
>.<<<<<..>>>>>...>>>>>>.........<<<....<<<........
..>>>..>>>..>....>>>....<<<...>>>.....<<<<........
....>>>.....>.........<<<<<((....<.<<<<.....<<..))
>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....
<<<<...<<<.......<.............>............<.....
...........<<<<.......>>>>.........>...<<<<<<<<...
....<<...<.......>..<<<..>>>.....>>......>>>>>..>>
>..........<<.<<.<<...}..}.)).))...>>.>>.>>.......
.......<...<.<....>.>....>..................<<<<<.
.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>
>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...
>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
>.........<<<.<<.<.<...<<<<<<...........>>>>>>...>
.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<
<<<<......<<........>>..........<<<<<.<....<<<<...
......<<.<<<........>>>.>>.......>>>>.<.<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<<<.....<<<<<<<.<<<<.................>
>>>.>>>>>>>.....>>>>....<<<<........>>>>.......>>>
>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<..<<.<.<..........>.>.>>...>.
.......>>>...>>>......<....<<<..<..........>..>>>.
....>.....>>>>>>....<<<<<<<.........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<
<<..<<<<<.<...<.<...>.>...>.>>>>>..>>>>.>.>>>.>>..
>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H37 Q43 R45 R46 K49 R57 N60 F64 R67 N69 G70 R71 K72 Q74 R77 R131 N134 Y138 F149 R150 L152 S154 M155
Binding residue
(residue number reindexed from 1)		H36 Q42 R44 R45 K48 R56 N59 F63 R66 N68 G69 R70 K71 Q73 R76 R123 N126 Y130 F141 R142 L144 S146 M147
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ868B1

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