Structure of PDB 8a98 Chain SH Binding Site BS01

Receptor Information
>8a98 Chain SH (length=184) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSKTPKLFNKWSFEGLETSELALRDHISTTAAYVPHTSGRWQKRRFYKAR
MPIVERLANGLMFKGRGNGRKLQAARLLKHTLEIIHLLTDENPLQVVVDA
VSKGAPREDSTRVGRRQAVDVSPMRRVNEAIYQMCKGAREAAFRNLKSMP
ECLADEIVNASKGSSNSYAIKKKDEVERVAKANR
Ligand information
>8a98 Chain S1 (length=1727) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcaugcaggaaucugcgcauggcucauuac
aucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaccgggugucuccacugaga
cgcccagcgaaugaaugacaguaaaaccaaugccugcaguaacacccagc
aguguugacucaauucauuccgcgaaagccggcuuccggcgucuuuugac
gaacaacugcccuaucagcuggugauggccguguaguggacugccauggc
guugacgggagcgggggauuaggguucgauuccggagagggagccugaga
aauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugu
caaaacaaaacgaugaggcagcgaaaagaaauagaguuguuucaaugggg
gauauuuaaacccaucccgaguaacaauuggaggacaagucuggugccag
cacccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguu
aaaggguucguaguugaacugugggcuggcccuugcagcccgugaaagaa
acaagaaacacgggagugguugcaugucaugcaugccguccgugauuuuu
uacugugacuaaagaagcgugacuaaagcagucaugacuugaauuagaaa
gcaugggauaacaaaggagcuuuuuaaagguauuggagauuauggagcug
ugcgacaaaugcuuucuaggaaugaaggaggguaguucgggggagaacgu
acuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacag
cgaaggcauucuucaaggauaccuuccucaaucaagaaccaaagugugga
gaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacac
ccaugaauuggggauaucuugcacguuuucuguuuucacgcgaaagcuuu
gagguuacagucucaggggggaguacguucgcaagagugaaacuuaaaga
aauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacu
caacacggggaacuuuaccagauccggacaggaugaggauugacagauug
aguguucuuucucgauucccugaaugguggugcauggccgcuuuuggucg
guggagugauuuguuugguugauuccgucaacggacgagauccaagcugc
ccaguagauuucagaauuuuucgggaauucuucucugcgggauuccuuug
uaugcacaaggugaaauuuugggcaacagcaggucugugaugcuccucaa
uguucugggcgacacgcgcacuacaaugucagugagaacaagaacgaacc
uacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugg
gaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguaggcg
cagcucaucaaacugugccgauuacgucccugccauuuguacacaccgcc
cgucguuguuuccgaugauggugcaauacaggugaucggacaggcgaaag
uucaccgauauuucuucaauagaggaagcaaaagucguaacaagguagcu
guaggugaaccugcagcuggaucauuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<.....<......>....>>.>>......<<......
..<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<
<<<<.....>>>>>>......>>..........<<<<<<<<<....>>>>
>>>>>.<<<<<<<<<<.....((.((.{..{<<..>>.............
............>>>>>>>>.>>....<<<<<...>>>>>...>>.>>..
>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>
......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<......
....>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<
<..........>>>..>>>..>....>>>....<<<....>>>.....<<
<<............>>>>.........<<<<<((....<.<<<<.....<
<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[
.....<<<<...<<<.......<...<.......>...>...........
.....<...............<<<<.......>>>>.........>...<
<<<<<<<.......<<...<.......>..<<<..>>>.....>>.....
.>>>>>..>>>..........<<.<<.<<.<...}..}.)).))>..>>.
>>.>>........................<<<<<..<<...<<<<<<<<.
.<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<
<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<
<...<<<<.<<<<<<.<.<.>.>.>>>>>>.>>>>....<<..]]>>...
..>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))
).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<...
.....>>..........<<<<<......<<<<.........<<.<<<...
.....>>>.>>.......>>>>.<.<<.<<<..<<.<<<<<<....<<<.
<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<
.....<<<.<<<.<<<...>>>..>>>.>>>.....>>>>....<<<<..
.......>>>>.......>>>>>....>>>.>>>.....>>>>>>>>...
...>>>>>...>>.>>>>>.>>.....<<<.<<<.......<......<<
<<<<<........>>>>>>>....>........>>>...>>>......<.
...<<<..<..........>..>>>.....>.....>>>>>>....<<<<
<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<............>
.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<
<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		H37 Q43 R45 R46 K49 N60 F64 R67 N69 G70 R71 K72 Q74 R77 N134 Y138 F149 R150 L152 M155
Binding residue
(residue number reindexed from 1)		H36 Q42 R44 R45 K48 N59 F63 R66 N68 G69 R70 K71 Q73 R76 N128 Y132 F143 R144 L146 M149
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ868B1

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