Structure of PDB 7wtq Chain SH Binding Site BS01

Receptor Information

>7wtq Chain SH (length=185) Species: 4932 (Saccharomyces cerevisiae)

APQAKILSQAPTELELQVAQAFVELENSSPELKAELRPLQFKSIREIDVA
GGKKALAIFVPVPSLAGFHKVQTKLTRELEKKFQDRHVIFLAERRILPKP
SRTSRQVQKRPRSRTLTAVHDKILEDLVFPTEIVGKRVRYLVGGNKIQKV
LLDSKDVQQIDYKLESFQAVYNKLTGKQIVFEIPS

Ligand information

>7wtq Chain C2 (length=1255)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauua
aaucaguuaucguuuauuugauaguuccucuacaugguauaacuguggua
auucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagaugua
uuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaaua
acuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucu
gcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgg
guaacggggaauaaggguucgauuccggagagggagccugagaaacggcu
accacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauuca
gggagguagugacaauaaauaacgauacagggucuuguaauuggaaugag
uacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugcc
agcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcag
uuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuccuu
cuggcuaaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcag
gcguauugcucgaauauauuagcauggaauaauagaauaggacguuuggu
ucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaa
ggcugaaacuuaaagaauugacggaagggcgcccuuuguaccgcccgucg
cuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaag
ggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuag
aggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggau
cauua

...<<<<<.[[[[.{>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<.......>>...>>.>>......<<.....
...<<<..<<..<<....<<<...............<<....<<.<<<..
...>>>.>>.....>>.........<<<<<..<<....>>..>>>>><..
.<<<<<<......(((((((.<<<....>>>..............>>>>>
>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>
>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>
.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>
>>..>>>..>....>.>.....<<<<<<<<....>>>>>.>>>......<
<..<...........>..>>.........<<<<<........<<<<.<<<
.<<....>>>>>....>>>>.>>>>>..>>>>>>>>>>.........<<<
[[.....<.<<...<<<.<<....<<<<<<.<<..>>.>>>>>>....<<
<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<
<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<
<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<.
..<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>.
.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>
....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>.
.>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....
>>>>....>>>..}]].]]..<<.<<<<<..>>>>>>>.<<<...<<.<.
.<<<<.<<..<<<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<
<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>>>
.>>.>>>>...>.>>......>>><<<<<<<<<....>>>>>>>>>....
.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wtq The nucleoplasmic phase of pre-40S formation prior to nuclear export.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): R96 R97 I98 P100 K101 R104 S106 R107 Q110 K111 R112 P113 R114 R116 T117 L118 K148 K179
• Binding residue (residue number reindexed from 1): R94 R95 I96 P98 K99 R102 S104 R105 Q108 K109 R110 P111 R112 R114 T115 L116 K146 K177

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7wtq, PDBe:7wtq, PDBj:7wtq
• PDBsum: 7wtq
• PubMed: 36321656
• UniProt: P26786|RS7A_YEAST Small ribosomal subunit protein eS7A (Gene Name=RPS7A)