Structure of PDB 6lqs Chain SH Binding Site BS01

Receptor Information
>6lqs Chain SH (length=182) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDEFKGYVF
KISGGNDKQGFPAIVGPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKR
ANNIRKFFGLSKEDDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRK
RHQRALKVRNAQAQREAAAEYAQLLAKRLSER
Ligand information
>6lqs Chain SA (length=1249) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucaaag
ccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaucagu
uaucguuuauuugauagcaugguauaacugugguaauucuagagcuaaua
caugcuaaucucgacccuuuggaagagauguauuuauuagagucuucgga
cucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggc
gaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagug
gccuaccaugguuucaacggggcaggcgcgcaaauuacccaauccuaauu
cagggagguagugacaauaaauaacgauacagggcccauucgggucuugu
aauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggc
aagucuggugccagcagccgcgguaauuccagcuccaauagcguauauug
cucguaguugaacuuugggcccgguuggccgguccggauuuccaacgggg
ccuuuccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauug
cucgaauauauuagcauggaauaauagaauagguugguucuauuucuagg
accugauuaauagggacggucgggggcaucaguauucaauugucagaggu
gaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaag
gacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaug
acccacucggcaccuugggggaguauggucgcaaggcugaaacuuaaagg
aauugacggaagggcaccaccaggaguggagccugcggcucaacacgggg
aaacucaccagguccagacacaauaaggauugacauucuugauuuugugg
gugguggugcauugaugcccuuguucugggcccgcgcgcuacacugacgg
agccagcgaguaacuccgucgugcugacgaggaauuccuaguaagcgcaa
gucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgu
cgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagaga
agggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuu
agaggaacuaaaaggguuuccguaggugaaccugcggaaggaucauuaa
..............................<..<<<<<<...<......<
<<.<<<..<<....<<....<<..........>>...>>.>>....<<<.
.<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>
>......<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>
>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>
>>....>>>...>>>>..>>>..<<....<<.....<<<<<<<<......
.>>>>>>>>.>>......>>.>>>>>>.........<<<....<<<....
.>>>..>>>.........>.....<<<<<<<..<<<<....>>>>..>>>
>.>>>......<<..<...........>..>>.........<<<<<<...
....<<<....>>>..................>>>>>>..>>>>>>.>.<
.<<...<<<.<<.....<<<<<.<<<<<..<.<...>.>..>>>>>.>>>
>>........<<<<<.<<............<.......>...<<.....>
>.............>>.>>..>>>..........<..<...<..>..>..
>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..
....>>>......>.>>>>>>..>>.......<<....>>...>>>>..>
.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<<........>
>>>>>>>>>>..>>>.....................<<.........>>.
....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.............
.........<<<......<<<<<.....................>>>>>.
......<<........>>......>>>.....>>>>.>>>.....<<<<<
<<...........>>>>>>>.............>>>>>>....<<<<<<<
<.......>>>>>>>>......>>...>>>>>>>............>>>>
>..<<<<.<<....<.<<<<.<..<<..<.<<......<<...<<.....
.<<<<....>>>>......>>...>>......>>.>..>>..>.>>>>>.
...>>.>>>>.......<<<<<<<<<....>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqs Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.8 Å
Binding residue
(original residue number in PDB)
K2 N4 Q13 S53 N56 Q59 V108 K131 R132 L133 G134 K136 R137 N139 N140 R154 R159 R160 Y169 K171 A172 P173 K174 I175 Q176 R177 L178 V179 Q182 R183 L184 Q185 R186 R188 Q190 K194 V195 N197 Q199 Q201 R202
Binding residue
(residue number reindexed from 1)
K2 N4 Q13 S53 N56 Q59 V71 K94 R95 L96 G97 K99 R100 N102 N103 R117 R122 R123 Y132 K134 A135 P136 K137 I138 Q139 R140 L141 V142 Q145 R146 L147 Q148 R149 R151 Q153 K157 V158 N160 Q162 Q164 R165
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6lqs, PDBe:6lqs, PDBj:6lqs
PDBsum6lqs
PubMed32943522
UniProtP0CX37|RS6A_YEAST Small ribosomal subunit protein eS6A (Gene Name=RPS6A)

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