Structure of PDB 7qca Chain SGG Binding Site BS01

Receptor Information

>7qca Chain SGG (length=319) Species: 1358809 (Spraguea lophii 42_110)

MISLNEKGSQYVHKQMVTCLEVPNEGNSDILYTASRDKKIYSILLKPEED
KVGKYIKSYEGHSGFVNCITTNSSNDKIISGSSDNTARIFDVESQKSVVL
KGHTRDITSISINTEDNKIITGSVDGKIMLWNTQGKCAEVFDNTHTSWIN
CVAFRPFNSNIVVSGSEDGTLKIWDIEEKRVMETFINGFSVTEIKEKGIE
IERKSAVTSLSMSPDGSLCAYGSKNSMVYVFKFDDNKCVINFDAGSTVKA
LAFGLTDVSIACATESEIILWDILKNVRIARIDYSSYGNGVYCTSLVWAK
DMLLAGFSDGRITAYERTI

Ligand information

>7qca Chain S60 (length=1354)

accagguugauucugccugacguggaugcuagucucauagauuuagccau
gcauguguaagcgaagcgauuagugaagcggcggaaggcucaguaacggg
cgaguauuuaaucucuagaaccggacaaccucaggaaacagaggggaaaa
cggaguaagagcauguguuagcaugugaugagaacaacagugcaggagag
uaagaagccaucccaucaguuaguaaguaggguaagggccuauuuagacg
uagacggguacgggggauuaggguuugauuccggagagggagccugagag
acggcuaccagguccaaggacagcagcaggcgcgaaaauuaccgaagccu
ccaagagggcgguagugaagagacgugaaaacaaguguguguaaaaacca
caugaguaacuggaggucaaggcuggugccagcauccgcgguaauaccag
cuccaggagugucuaugaugauugcugcgauuaaaagguccguagucgaa
gaacaguacuuguuuguaauguggcuuaucgagagccgaauagaacgaga
agaguucagaguaaggagcgaaggagggcuagauuauugagcagcgagag
gugaaauuugaugaccugcuuaggaguaacagaggcgaaagcgcuaguca
agaacgaauccgaugaucaaggacguaggcuggaggaucgaagacgauua
gagaccguaguaguuccagcaguaaacgaugccuacgcuguugugguuau
gagcacggcagaagagaaaucuaguagggcuuuggggagaguacgcgcgc
aagcgauaaauuuaaaggaaauugacggaagaacaccacaaggaguggag
ugugcggcuuaauuugacucaacgcgggacagcuuaccauacccgauggc
cgugugagcguaguacgcgauaggucagagaguggugcauggccguuaac
gacgaguggggugaccuuuggguuaaguccgcgaaguagugagaucccua
ggauacgaaaguuaucgacagguguuaaaaacacaggaaggaaggggcaa
gaacaggucagugaugcccuuagaugguaugggcugcacgcgcacuacag
uggucacagcagaaacaaauagaaguaaaugugaucgagagggaaugagc
acuguaaugugcacaggaacgaggaauugcuaguaaucguuaucucauua
agaagcgaugaaugugucccuguucuuuguacacaccgcccgucguuauc
gaagauggaaccaggugcgaacaagugaaagcgagugagugcaggguucu
agaucugauacaagucguaacaaggcagcuguaggagaaccuguagcugg
auca

..<<<<<.[.(((.>>>>>.<<<<<<<<<..<<<<<.<.......<<<.<
<<..<<....<<...<<.....>>...>>.>>......<<.......<<<
<.....<<...<<<<<.<..<<<.....<<<<.<....>.>>>>......
>>>....<..<<<<<<....>>>>>>..>....<<....>>.>.>>>>>.
.>>...>>>.><<<....<<<..<<<<<<<<.......>>>>>>>>>>>.
.....>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>..<<<<..>>>>....>>>>>>.........<<<....<<<
<...>>>>..>>>...>..>>>>>..........<<<<<.........>>
>>>......<<<<<((....<.<<<<.....<<..))>>.......>>>>
>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<...
<<<<....<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>.
...>>>>.......<<<.<<......<<<<<<..<.<<<<<<<<...<<<
......>>>......>>>>>>>>..>........<<....>>.>>>>>>.
....>>..>>>...>>>...>>>>..<.<<<<<<<...<....<<<....
.....>>>....>>>>>>>>..>.......<<<.<<.<<<<<<<<.<<..
>>.>>>>>>>>..<<..))>>..>>..>>>.>>>.<<<.......<<<..
..>>>.....>>>....))).]<<<<<.<<<<<<<..<<.<<.<<<..<<
<<<<<<<<......<<........>>..........<<<<<<<...<<<<
<......<<<<...>>>>....>>>>>..<<<.<<<..<<.<<<<<<...
.<<.<..<<<....>>>...<<......>>......>.>>....<<<<<.
<..<<<....>>.>.>.....<<<<.....>>>>........>>>>>...
.>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>....
.<<<<<<<.....................>>>>>>>....<....<<.<<
<<......>>>>.>>....>.....>>>.>>....<<<<<..<<......
.>>.>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<
<.<...<<<<<<..<<<<..<<..<<....>>..>>..>>>>..>>>>>>
...>.>>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>..
....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qca Spraguea lophii ribosome
• Resolution: 2.79 Å
• Binding residue (original residue number in PDB): K14 D84 T86 R88 N293
• Binding residue (residue number reindexed from 1): K14 D84 T86 R88 N289

Gene Ontology

Molecular Function

• GO:0005080 protein kinase C binding
• GO:0043022 ribosome binding
• GO:0045182 translation regulator activity

Biological Process

• GO:0001934 positive regulation of protein phosphorylation
• GO:0006417 regulation of translation
• GO:0072344 rescue of stalled ribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:7qca, PDBe:7qca, PDBj:7qca
• PDBsum: 7qca
• UniProt: S7XVG3