Structure of PDB 8rxh Chain SG Binding Site BS01

Receptor Information
>8rxh Chain SG (length=229) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNIAYPRNGTVKQFEISDEVLRRVQLQDYRLGNEVDGAIFGSEFKGYI
FRLRGGSDKDGFPMVPGVLASSRVSLLVKRGAIGFNTFRGYQGERRRKNV
RGCVLASDIALVNVTISKVGDQPIEGVTDTTAPRRLGPKRASKIRKLFNL
SRTEDVRKYVVRRRVVDRLKAPKIQRLITPRVKARRAKKAKDAIAKVRAS
AAERREYLRLIASNRRALRQRDHSKKHTR
Ligand information
>8rxh Chain S1 (length=1844) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuu
ggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugag
acgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacaccca
gcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcguc
uuuugacgaacaacugcccuaucagcuggugauggccguguaguggacug
ccauggcguugacgggagcgggggauuaggguucgauuccggagagggag
ccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugc
ccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagaguuguuug
ucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauugg
aggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcgua
uauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugc
agggcccuugcagcccgugaaaaagaaacaagaaacacgggagugggucg
caugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaa
gcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaa
aggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucu
auuggagauuauggagcuguuucccacggugugacggccucuaggaauga
aggaggguaguucgggggagaacguacuggggcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauug
uaguccacacugcaaacgaugacacccaugaauuggggauacuuaguauc
uuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucu
caggggggaguacguucgcaagagugaaacuuaaagaaauugacggaaug
gcaccacaagacguggagcgugcgguuuaauuugacucaacacggggaac
uuuaccagauccggacaggaugagauugacagauugaguguucuuucucg
auucccugaaugguggugcauggccgcuuauggucgguggagugauuugu
uugguugauuccgucaacggacgagauccaagcugcccaguagaauucag
aauugcccauaggauagcgcauucggucgaauucuucucugcgggauucc
uuuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcu
ccucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaa
aaacgaucgaaccuacuugaucaaaagaguggggaaaccccggaaucaca
uagacccacuugggaccgaggauugcaauuauuggucgcgcaacgaggaa
ugucucguaggcgcagcucaucaaacugugccgauuacgucccugccauu
uguacacaccgcccgucguuguuuccgaugauggugcaauacaggugauc
ggacaggcgcccgaaaguucaccgauauuucuucaauagaggaagcaaaa
gucguaacaagguagcuguaggggaaccugcagcugggacauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
.<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<
<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>
>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>...........
..............>>>>>>>>...>>....<<<<<......>>>>>...
>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>
>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<
<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<
<....<<<..........>>>..>>>..>....>>>....<<<.<<....
.>>.>>>.....<<<<............>>>.....>.........<<<<
<<<........((.....((..>>)).......))...>>>>>..>>>>>
>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<.
.<..>.>.>>...>...................<...............<
<<<.......>>>>.............>.....<<<<<<<<.......<<
...<.......>..<<<....>>>.....>>......>>>>>..>>>...
........<<..<<<<<<.<<<...>>>.....)))).)))))..>>>>>
>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>........
....<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>.
.....>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<.
.........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.
>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<
<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>......
....<<<<<.<....<<<<........<<.<<<........>>>.>>...
....>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>..
.<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<
<<<.................>>>>....>>>>>>>.....>>>>....<<
<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>
>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<..
...<<..>>..<<<<<<<........>>>>>>>....>........>>>.
..>>>......<....<<<..<..........>..>>>.....>.....>
>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>
>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<
...<.<....>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..
>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)
N4 P8 V13 Q15 R32 L33 G34 R54 D60 G61 P63 G67 V68 R73 L76 L77 I83 G84 F85 N86 R89 Y91 Q92 G93 E94 R95 R96 R97 N99 L111 N113 R134 R135 L136 G137 K139 R140 S142 K143 R145 R152 R163 D172 R173 K175 P177 K178 Q180 R181 I183 R186 K188 R190 R191 A195 I199 K201 R203 S205 R210 L213 A217 R220 R221 R224 Q225 R226 H228
Binding residue
(residue number reindexed from 1)
N4 P8 V13 Q15 R32 L33 G34 R54 D60 G61 P63 G67 V68 R73 L76 L77 I83 G84 F85 N86 R89 Y91 Q92 G93 E94 R95 R96 R97 N99 L111 N113 R134 R135 L136 G137 K139 R140 S142 K143 R145 R152 R163 D167 R168 K170 P172 K173 Q175 R176 I178 R181 K183 R185 R186 A190 I194 K196 R198 S200 R205 L208 A212 R215 R216 R219 Q220 R221 H223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ9NE83|RS6_LEIMA Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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