Structure of PDB 7wtl Chain SG Binding Site BS01

Receptor Information
>7wtl Chain SG (length=218) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDEFKGYVF
KISGGNDKQGFPMKQGVLLPTRIKLLLTKNVSCYRPRRDGERKRKSVRGA
IVGPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKRANNIRKFFGLSKE
DDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRHQRALKVRNAQA
QREAAAEYAQLLAKRLSE
Ligand information
>7wtl Chain C2 (length=1102) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauua
aaucaguuaucguuuauuugauaguuccucuacaugguauaacuguggua
auucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagaugua
uuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaaua
acuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucu
gcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgg
guaacggggaauaaggguucgauuccggagagggagccugagaaacggcu
accacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauuca
gggagguagugacaauaaauaacgauacagggucuuguaauuggaaugag
uacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugcc
agcagccgcgguaauuccagcuccaauagcguauauuauguugcaguuaa
aaagcucguaguugaacuuugggcccgguuaacggggccuuuccuucugg
cuaaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgu
auugcucgaauauauuagcauggaauaauagaauaggacguuugguucua
uuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggg
caucaguauucaauugucagaggugaaauucuuggauuuauugaagacua
acuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaa
guuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacu
augccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccu
uacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcu
gaaacuuaaaggaauugagguuuccguaggugaaccugcggaaggaucau
ua
...<<<<<.{{[[[[>>>>>[[[..((((((................[[[
.[[[..<<....<<....<<.......>>...>>.>>......{{.....
...[[[..{{..{{....[[[...............<<....<<.<<<..
...>>>.>>.....>>.........<<<<<..<<....>>..>>>>>[..
.((((((......<<<<<<<<<<<....>>>....<<......>>)))))
).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]
].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>
.>>.<.<<<..>>>.>...]]]]]].........<<<....<<<.....>
>>..>>>...............<<<<<<<<....>>>>>.>>>......<
<..<...........>..>>.........<<<<<........<<<<.<<<
.<<....>>>>>....>>>>.>>>>>..)))))).]]].....[[[{{..
.....{{...[[[.{{....<<<<<<.<<..>>.>>>>>>....<<<<<<
.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<..
...>>>....>>......>>.>>..>>>.........[[[..((((((((
....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<
<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.
......<<....>>...>>>>...>>>>>.>>>...]]]...}}......
<<<<<<..<.<...<<<...........>>>...>>>>>>>>........
..<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>
...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>
....>>>..]]]].}}.....<<<<<<<<<....>>>>>>>>>.......
..
Receptor-Ligand Complex Structure
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PDB7wtl In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
K2 N4 P8 Q13 T15 S53 N56 K58 Q59 G60 P62 R72 S82 C83 R85 R87 R88 G90 R92 R94 S96 V108 R132 L133 G134 K136 R137 N139 N140 K143 R154 R159 R160 K164 Y169 T170 K171 A172 P173 K174 Q176 R177 L178 V179 R183 L184 Q185 R186 K187 R188 Q190 R191 K194 V195 A198 Q199 Q201 R202 L216
Binding residue
(residue number reindexed from 1)
K2 N4 P8 Q13 T15 S53 N56 K58 Q59 G60 P62 R72 S82 C83 R85 R87 R88 G90 R92 R94 S96 V108 R132 L133 G134 K136 R137 N139 N140 K143 R154 R159 R160 K164 Y169 T170 K171 A172 P173 K174 Q176 R177 L178 V179 R183 L184 Q185 R186 K187 R188 Q190 R191 K194 V195 A198 Q199 Q201 R202 L216
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7wtl, PDBe:7wtl, PDBj:7wtl
PDBsum7wtl
PubMed36263816
UniProtP0CX37|RS6A_YEAST Small ribosomal subunit protein eS6A (Gene Name=RPS6A)

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