Structure of PDB 8g6j Chain SF Binding Site BS01

Receptor Information
>8g6j Chain SF (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQ
CPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNA
IINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRN
IKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Ligand information
>8g6j Chain S2 (length=1701) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccacuuggauaacuguggua
auucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggg
augcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcac
gccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuuc
gaugguagucgccgugccuaccauggugaccacgggugacggggaaucag
gguucgauuccggagagggagccugagaaacggcuaccacauccaaggaa
ggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacga
aaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucca
cuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagca
gccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaa
aaagcucguaguuggaucuugggagcgggcguccccgccuuuacuuugaa
aaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuag
gaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugag
gccaugauuaagagggacggccgggggcauucguauugcgccgcuagagg
ugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaa
gaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucag
auaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggc
guuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggg
uuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaa
gggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaa
accucacccggcccggacacggacaggauugacagauugauagcucuuuc
ucgauuccgugggugguggugcauggccguucuuaguugguggagcgauu
ugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguua
cgcgacccccgagcggucggcgucccccaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu
a
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..........<<.....<<.<<<..
...>>>.>>......>>.........<<<<...<<<<<......>>>>>.
..>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<
<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<...
.<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<...
.>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.
>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>
.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<
...........>..>>.........<<<<<((....<.<<<<.....<<.
.))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((..
...<.<<...<<<.<<........................<<<<<<.<..
.....<<...<.......>.<<<<.......>>>>...>>......>.>>
>..>>>........<.<<.<<<<<<<...............>>>>>>>.>
>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<.
.....>>>......>>>>>>>>..>>.......<<....>>...>>>>..
>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<...
..>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.
<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>
>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<
<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>....
......<<<<<......<<<<<<.......<<.<<<........>>>.>>
.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>
>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<
<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
..>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>............
<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<...
.......>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g6j mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H51 A57 K59 R60 K63 R71 N74 M76 M78 H79 R81 N82 N83 G84 K85 K86 M88 R145 N148 W152 R159 R164 N165 I166 T168 I169
Binding residue
(residue number reindexed from 1)		H36 A42 K44 R45 K48 R56 N59 M61 M63 H64 R66 N67 N68 G69 K70 K71 M73 R130 N133 W137 R144 R149 N150 I151 T153 I154
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006450 regulation of translational fidelity
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g6j, PDBe:8g6j, PDBj:8g6j
PDBsum8g6j
PubMed37020024
UniProtP46782|RS5_HUMAN Small ribosomal subunit protein uS7 (Gene Name=RPS5)

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