Structure of PDB 8bsi Chain SF Binding Site BS01

Receptor Information
>8bsi Chain SF (length=177) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LFNKWPLTDVKCQDESLEAYISIDNHSFVPHSAGRWSAKRFRKAKCPVVE
RLTNSLMMHGRNSGKKLMAMKTVGEAFELINLYTGKNPVQVLVDAVANSG
PREDSCRIRQSVDVSPLRRVNIGIYNIATGARKAAFRKVRPFAECLAEEI
MNAAAGADKSYAISQRNSVERIAVSNR
Ligand information
>8bsi Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<<.............<<.....<<<<<<....>>>>>>..
....>>...<....<.<.<<<<...[.[...<.....>..>>>>.>>...
>....>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<<..>>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>..>...>>>>>............<
<<<<<.........>>>>>>.....<<<<<<<......[..[.....((.
.>>)).......]..].>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<..<<.......
>>...........>>......>>>>>..>.>>>..<<<<<<.....].].
.>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<
..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..
>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<<<......<<........>>........
.<<<<<......<<<<<<......<<<.<<<.......>>>.>>>....>
>>>>>...<..<<<..<<.<<<<<<....<<.<<<<<<....>>>....<
<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<
<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>.>..
.....>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<.
...>>.>>>.......>>>>>>>...........<<.<<<<......>>>
>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....
....
Receptor-Ligand Complex Structure
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PDB8bsi Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		H37 S43 K45 R46 K49 N60 L62 M63 M64 H65 G66 R67 N68 S69 G70 K71 K72 L73 M74 R131 N134 Y138 R145 F149 R150 V152 P154 F155
Binding residue
(residue number reindexed from 1)		H31 S37 K39 R40 K43 N54 L56 M57 M58 H59 G60 R61 N62 S63 G64 K65 K66 L67 M68 R118 N121 Y125 R132 F136 R137 V139 P141 F142
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bsi, PDBe:8bsi, PDBj:8bsi
PDBsum8bsi
PubMed36912103
UniProtA8BZD3

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