Structure of PDB 6xa1 Chain SF Binding Site BS01

Receptor Information
>6xa1 Chain SF (length=185) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQ
CPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNA
IINSGPREDSTRITVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTI
AECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Ligand information
>6xa1 Chain S2 (length=1590) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
uggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguag
ucgccgugccuaccauggugaccacgggugacggggaaucaggguucgau
uccggagagggagccugagaaacggcuaccacauccaaggaaggcagcag
gcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaac
aauacaggaccuguaauuggaaugaguccacuuuaaauccuuuaacgagg
auccauuggagggcaagucuggugccagcagccgcgguaauuccagcucc
aauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuu
uuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgugaggccaugauuaagagggacg
gccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcg
caagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaa
gaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgac
cauaaacgaugccgaccggcgaugcggcggcguuauugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccagcggucggcguaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacugg
cucagcguguccuacgccggcaggcgcggguaacccguugaaccccauuc
gugauggggaucggggauugcaauuauuccccaugaacgaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuguaca
caccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggauc
ggccgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<<.........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.
.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<
.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>...
.>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>
>>.........<<<....<<<<...>>>>..>>>......>>.>.....<
<<<<<<<<.>>>>>>.>>>......<<..<...........>..>>....
.....<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>
>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....
.<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>....
..>.>>>..>>>........<.<<.<..>.>>.>....>>....<<<<<<
..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>
>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
..........<<<.<<.<<<..<.<<<<<<.<<<<.>>>>>>>>>>.>..
>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<
........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>
......<.....<<<<<..........>>>>>.....>.....>>>>>..
...<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>
....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<
<<<.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xa1 Selective inhibition of human translation termination by a drug-like compound.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H51 A57 R60 K63 N74 H79 G80 R81 N82 N83 G84 K86 M88 N148 R159 F163 R164 I166 T168 I169
Binding residue
(residue number reindexed from 1)		H36 A42 R45 K48 N59 H64 G65 R66 N67 N68 G69 K71 M73 N129 R140 F144 R145 I147 T149 I150
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006450 regulation of translational fidelity
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum6xa1
PubMed33009412
UniProtP46782|RS5_HUMAN Small ribosomal subunit protein uS7 (Gene Name=RPS5)

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