Structure of PDB 6lqs Chain SF Binding Site BS01

Receptor Information
>6lqs Chain SF (length=250) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNRLKYALNG
REVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLVYDVKGR
FAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVND
TVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLV
HIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQ
Ligand information
>6lqs Chain SA (length=1249) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucaaag
ccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaucagu
uaucguuuauuugauagcaugguauaacugugguaauucuagagcuaaua
caugcuaaucucgacccuuuggaagagauguauuuauuagagucuucgga
cucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggc
gaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagug
gccuaccaugguuucaacggggcaggcgcgcaaauuacccaauccuaauu
cagggagguagugacaauaaauaacgauacagggcccauucgggucuugu
aauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggc
aagucuggugccagcagccgcgguaauuccagcuccaauagcguauauug
cucguaguugaacuuugggcccgguuggccgguccggauuuccaacgggg
ccuuuccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauug
cucgaauauauuagcauggaauaauagaauagguugguucuauuucuagg
accugauuaauagggacggucgggggcaucaguauucaauugucagaggu
gaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaag
gacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaug
acccacucggcaccuugggggaguauggucgcaaggcugaaacuuaaagg
aauugacggaagggcaccaccaggaguggagccugcggcucaacacgggg
aaacucaccagguccagacacaauaaggauugacauucuugauuuugugg
gugguggugcauugaugcccuuguucugggcccgcgcgcuacacugacgg
agccagcgaguaacuccgucgugcugacgaggaauuccuaguaagcgcaa
gucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgu
cgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagaga
agggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuu
agaggaacuaaaaggguuuccguaggugaaccugcggaaggaucauuaa
..............................<..<<<<<<...<......<
<<.<<<..<<....<<....<<..........>>...>>.>>....<<<.
.<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>
>......<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>
>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>
>>....>>>...>>>>..>>>..<<....<<.....<<<<<<<<......
.>>>>>>>>.>>......>>.>>>>>>.........<<<....<<<....
.>>>..>>>.........>.....<<<<<<<..<<<<....>>>>..>>>
>.>>>......<<..<...........>..>>.........<<<<<<...
....<<<....>>>..................>>>>>>..>>>>>>.>.<
.<<...<<<.<<.....<<<<<.<<<<<..<.<...>.>..>>>>>.>>>
>>........<<<<<.<<............<.......>...<<.....>
>.............>>.>>..>>>..........<..<...<..>..>..
>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..
....>>>......>.>>>>>>..>>.......<<....>>...>>>>..>
.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<<........>
>>>>>>>>>>..>>>.....................<<.........>>.
....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.............
.........<<<......<<<<<.....................>>>>>.
......<<........>>......>>>.....>>>>.>>>.....<<<<<
<<...........>>>>>>>.............>>>>>>....<<<<<<<
<.......>>>>>>>>......>>...>>>>>>>............>>>>
>..<<<<.<<....<.<<<<.<..<<..<.<<......<<...<<.....
.<<<<....>>>>......>>...>>......>>.>..>>..>.>>>>>.
...>>.>>>>.......<<<<<<<<<....>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqs Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		S24 Y27 A28 P29 R30 A33 G34 R49 N57 G58 R59 M66 K75 R77 K128 L131 K133 K134 Y138 T146 R187 N188 D202 V219 R255 Q258
Binding residue
(residue number reindexed from 1)		S16 Y19 A20 P21 R22 A25 G26 R41 N49 G50 R51 M58 K67 R69 K120 L123 K125 K126 Y130 T138 R179 N180 D194 V211 R247 Q250
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032991 protein-containing complex
GO:0043232 intracellular non-membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqs, PDBe:6lqs, PDBj:6lqs
PDBsum6lqs
PubMed32943522
UniProtP0CX35|RS4A_YEAST Small ribosomal subunit protein eS4A (Gene Name=RPS4A)

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