Structure of PDB 8oo0 Chain SD Binding Site BS01

Receptor Information
>8oo0 Chain SD (length=214) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QISKKRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRAT
HTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCE
SLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFT
DGFMIHSGQPAREFIDTATRHVLLRQGVLGIKVKIMRGKTLPDVVTVIEP
KEETPVVQPMSQDY
Ligand information
>8oo0 Chain 2 (length=1765) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauucugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuauacagcgaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauaguuacauggauaaccgugguaauuc
uagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauu
agauuaaaaaccaaugcccuucggggcuuucuggugauucauaauaacuu
cucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugccc
uaucaacuuucgacggcuggguauuggccagccguggugacaacggguaa
cggaggguuagggcucgaccccggagaaggagccugagaaacggcuacua
cauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacgggga
gguagugacaauaaauacugauacagggcucuuucgggucuuguaauugg
aaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucu
ggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguug
uugagguuaaaaagcucguaguugaaccuugggccuagcccgccgguacu
ggcugggcugggccuuuccuucuggagaaccgcaugccggugugucgggg
aaccaggacuuuuacucugaacaaauuagaucgcuuaaagaaggccuaug
cuugaauacauuagcauggaauaauagaauaggacgugugguucuauuuu
guugguuucuaggaccgccguaaugauuaauagggacagucgggggcguc
aguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaa
cugcgaaagcauucgccaaggauguuuucauuaaucaggaacgaaaguua
ggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugc
cgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacga
uaaaucaaaauguuugggcuccugggggaguauggucgcaaggcugaaac
uuaaagaaauugacggaagggcaccaccagggguggagccugcggcuuaa
uuugacucaacacggggaaacucaccagguccagacacgaugaggauuga
cagauugagagcucuuucuugauuucgugggugguggugcauggccguuc
uuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccu
uaaccugcuaaauagcccguauugccuuggcaguacgccggcuucuuaga
gggacuaucggcucaagccgauggaaguuugaggcaauaacaggucugug
augcccuuagauguucugggccgcacgcgcgcuacacugacagagccagc
gaguacucccuuggccgagaggcccggguaaucuuguuaaacucugucgu
gcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacaca
ccgcccgucgcuacuaccgauugaacggcucagugaggcuuucggacugg
cccagagaggucggcaacgaccacucagggccggaaaguuauccaaacuc
ggucguuuagaggaaguaaaagucguaacaaggucuccguaggugaaccu
gcggagggaucauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<..........<<<
.<<<..<<....<<....<<.........>>...>>.>>......<<...
.....<<<..<<..<<....<<<........<<.....<..<<.......
>>..>......>>........<<<<<..........>>>>><...<<<<<
<......(((((((.<<<<<..>>>>>.....<......>.>>>>>>...
..>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<
<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.
..<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..
>>>.......>.>....<<<<<<<<<<<<<......>>>>>>>>.>>>>>
.....<<..<...........>..>>.........<<<<<((......<<
<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>......
...<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<<<<<..>>
>>>.>>>>>>>>>>>....<<<<<<....<<<...<<..>>....>>>..
..>>>>>>...<<<<<.<<.......<<..<<.......>>.<<<....>
>>....>>......>>.>>..>>>.........<<<.<<<<<<<<<....
.))))))).>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..
<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.....
..<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<
<<<...<...<<<<.........>>>>...>>>>>>>>..........<<
<.<<.<<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>>...<<
..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>
>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<......<<<<<........<<
.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<.
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>>>..>>>>..>>>>.
>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>.....
>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<.....
.<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>..
....<....<<<<<<..........>>>>>>....>.....>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<
<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>..>>>.
>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>
>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oo0 Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Q7 I8 S9 K10 K11 R12 K144 R146 R149 F159 H162 S163 G164 Q165 H177 Q182 V184 D209
Binding residue
(residue number reindexed from 1)		Q1 I2 S3 K4 K5 R6 K138 R140 R143 F153 H156 S157 G158 Q159 H171 Q176 V178 D193
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8oo0, PDBe:8oo0, PDBj:8oo0
PDBsum8oo0
PubMed38267453
UniProtG0S6I7

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