Structure of PDB 8ovj Chain SC Binding Site BS01

Receptor Information
>8ovj Chain SC (length=212) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLSKKRMIIRDGVFYAELFEFLKRELAEEGFSGVSYHVTTLRTEIVIKA
TKTREVLGVNGRRIRELTACIQQRFNYKEGKLQLYVERVEVRGLSAMAQV
ESLRFKLLSNLQVRRAAMGIIRYVMESGAKGCEVTVGGKIKGQRAKSMTF
RDGYMIKSGTAHKSFVDSACRHCYMRAGCIGVKVKIMLPGDSTGRNGPSE
PLPDVITVIEPK
Ligand information
>8ovj Chain S1 (length=1755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggc
gaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccag
cgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguuga
cucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacug
cccuaucagcuggugauggccguguaguggacugccauggcguugacggg
agcgggggauuaggguucgauuccggagagggagccugagaaauagcuac
cacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaa
acgaugaggcagcgaaaagaaauagaguuuuucaaugggggauauuuaaa
cccauccaauaucgaguaacaauuggaggacaagucuggugccagcaccc
gcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaagg
guucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacac
gggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacu
aaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggaua
acaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugc
uuucccaucucggugugggguuuacggccucuaggaaugaaggaggguag
uucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcac
caagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaa
gaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacac
ugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuu
uuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaag
agugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgug
cgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaug
aggauugacagauugaguguucuuucucgauucccugaaugguggugcau
ggccgcuuauggucgguggagugauuuguuugguugauuccgucaacgga
cgagauccaagcugcccaguagaauucagaauugcccauaggauagcgca
uucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaacuacuugaucaaaagaguggggaaacc
ccggaaucacauagacccacuugggaccgaggauugcaauuauuggucgc
gcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacg
ucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaa
uacaggugaucggacagggcccgaaaguucaccgauauuucuucaauaga
ggaagcaaaagucguaacaagguagcuguaggggaaccugcagcugggac
auuuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<
.....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<
<<<<<<<<<.....((.((.{..{<<.>>.....................
....>>>>>>>>>>....<<<<<...>>>>>...>>.>>..>>>>..>>>
.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>
..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>
>.<<<<<..>>>>>...>>>>>>.........<<<....<<<........
..>>>..>>>..>....>>>....<<<...>>>.....<<<<........
....>>>.....>.........<<<<<((....<.<<<<.....<<..))
>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....
<<<<...<<<.......<.............>............<.....
...........<<<<.......>>>>.........>...<<<<<<<<...
....<<...<.......>..<<<..>>>.....>>......>>>>>..>>
>..........<<.<<.<<...}..}.)).))...>>.>>.>>.......
.......<...<.<....>.>....>..................<<<<<.
.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>
>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...
>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
>.........<<<.<<.<.<...<<<<<<...........>>>>>>...>
.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<
<<<<......<<........>>..........<<<<<.<....<<<<...
......<<.<<<........>>>.>>.......>>>>.<.<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<<<.....<<<<<<<.<<<<.................>
>>>.>>>>>>>.....>>>>....<<<<........>>>>.......>>>
>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<..<<.<.<..........>.>.>>...>.
.......>>>...>>>......<....<<<..<..........>..>>>.
....>.....>>>>>>....<<<<<<<.........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<
<<..<<<<<.<...<.<...>.>...>.>>>>>..>>>>.>.>>>.>>..
>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G2 P3 K7 R8 R26 G139 K140 Q144 R145 A146 Y155 M156 K158 S159 G160 T161 A178 C180 K184 P204 D205
Binding residue
(residue number reindexed from 1)		G1 P2 K6 R7 R25 G138 K139 Q143 R144 A145 Y154 M155 K157 S158 G159 T160 A177 C179 K183 P203 D204
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4Q4A0

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