Structure of PDB 6xa1 Chain SC Binding Site BS01

Receptor Information
>6xa1 Chain SC (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLK
IMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILA
KLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAP
VPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKE
TVFTKSPYQEFTDHLVKTHT
Ligand information
>6xa1 Chain S2 (length=1590) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
uggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguag
ucgccgugccuaccauggugaccacgggugacggggaaucaggguucgau
uccggagagggagccugagaaacggcuaccacauccaaggaaggcagcag
gcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaac
aauacaggaccuguaauuggaaugaguccacuuuaaauccuuuaacgagg
auccauuggagggcaagucuggugccagcagccgcgguaauuccagcucc
aauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuu
uuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgugaggccaugauuaagagggacg
gccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcg
caagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaa
gaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgac
cauaaacgaugccgaccggcgaugcggcggcguuauugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccagcggucggcguaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacugg
cucagcguguccuacgccggcaggcgcggguaacccguugaaccccauuc
gugauggggaucggggauugcaauuauuccccaugaacgaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuguaca
caccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggauc
ggccgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<<.........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.
.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<
.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>...
.>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>
>>.........<<<....<<<<...>>>>..>>>......>>.>.....<
<<<<<<<<.>>>>>>.>>>......<<..<...........>..>>....
.....<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>
>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....
.<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>....
..>.>>>..>>>........<.<<.<..>.>>.>....>>....<<<<<<
..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>
>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
..........<<<.<<.<<<..<.<<<<<<.<<<<.>>>>>>>>>>.>..
>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<
........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>
......<.....<<<<<..........>>>>>.....>.....>>>>>..
...<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>
....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<
<<<.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB6xa1 Selective inhibition of human translation termination by a drug-like compound.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		V112 Q113 K114 Q115 T116 R117 A118 Q120 K125 T185 R187 G189 S190 L192 R194 V205 S206 A207 Y223 T224 R227 T230 T232 N235 K238
Binding residue
(residue number reindexed from 1)		V54 Q55 K56 Q57 T58 R59 A60 Q62 K67 T127 R129 G131 S132 L134 R136 V147 S148 A149 Y165 T166 R169 T172 T174 N177 K180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum6xa1
PubMed33009412
UniProtP15880|RS2_HUMAN Small ribosomal subunit protein uS5 (Gene Name=RPS2)

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