Structure of PDB 8btd Chain SB Binding Site BS01

Receptor Information
>8btd Chain SB (length=216) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEWHPSTKLGRLVKAGKIESLYDIFKYSLPIKETEIIDYFFPKSELAEEV
CNIMSVQKQTTAGQRTRFRAHVIVGNRDGFIGYGAGVSKEVANAIKKAAK
NARLNIVPVRRGFWGGKLGDPHTVSSKLSGKCGSVRVRLIPAPRGAGIVA
SPTVAKVLEFAGVSDVFTRQSGHSRTLMNSVGAVYNALKSSYSILTPDLW
KKEQLDHVQDIRTMSL
Ligand information
>8btd Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<.........<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<..............<<.....<<<<<<....>>>>>>..
....>>........<<..<<<<...[.....<.....>..>>>>.>>...
.......>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>......>>>>>............<
<<<<<.........>>>>>>.....<<<<<<<.........[.....((.
.>>)).......]....>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<...<.......
>............>>......>>>>>..>.>>>..<<<<<<.......].
.>>>..>>>..........<<<<<<<.<...<<<<..<<..<<<<<.<<<
..<..........>.....>>>.>>>>.>.>>.......<<....>>...
>>>>..>.>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<........<<........>>........
.<<<<<......<<<<<<......<<..<<<.......>>>..>>....>
>>>>>...<<.<<<.....<<<<<<....<<.<<<<<<....>>>....<
<......>>....>>>.>>....<<<...<<<<<.....>>>>>.....<
<<<<....>>>>>.........>>>....>>>.>>>.......>>>>>..
.....>>>>>......>>>>.>>>.....<<<.<<<.....<.<<<.<<.
...>>.>>>..>....>>>.>>>......<....<<.<<<<......>>>
>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8btd Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution4.9 Å
Binding residue
(original residue number in PDB)		V80 Q81 K82 Q83 T84 T85 A86 R89 R93 K124 K151 S153 K155 S158 R160 R162 V173 A174 S175 P176 F191 T192 R193 Q194 S195 H197 S198 R199 N203
Binding residue
(residue number reindexed from 1)		V56 Q57 K58 Q59 T60 T61 A62 R65 R69 K100 K127 S129 K131 S134 R136 R138 V149 A150 S151 P152 F167 T168 R169 Q170 S171 H173 S174 R175 N179
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8btd, PDBe:8btd, PDBj:8btd
PDBsum8btd
PubMed36912103
UniProtA8BMZ1

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