Structure of PDB 8rxh Chain SA Binding Site BS01

Receptor Information
>8rxh Chain SA (length=244) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALGKNKRISKGGKRGRGKAETMARKEWYDVVAPANFEKRQFAKTICNKTQ
GTRIAADVLRGRVFEANLADLNQSAGEEEAYRKVRFTVQEVQGRNLLTQF
HSMEVTTDKMASLLRKWCTTMETTVEVKTADGYTMRLFVVAFTKPQANQQ
SRNCYAKQRLVKWLRMRITKMIKRRLSKVQIKEAVSLLTRNVLSDALVRR
CNPILPLRELRIRKVRVVRTPKFDAQALLSAHGTIPASVEADQR
Ligand information
>8rxh Chain S1 (length=1844) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuu
ggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugag
acgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacaccca
gcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcguc
uuuugacgaacaacugcccuaucagcuggugauggccguguaguggacug
ccauggcguugacgggagcgggggauuaggguucgauuccggagagggag
ccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugc
ccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagaguuguuug
ucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauugg
aggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcgua
uauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugc
agggcccuugcagcccgugaaaaagaaacaagaaacacgggagugggucg
caugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaa
gcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaa
aggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucu
auuggagauuauggagcuguuucccacggugugacggccucuaggaauga
aggaggguaguucgggggagaacguacuggggcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauug
uaguccacacugcaaacgaugacacccaugaauuggggauacuuaguauc
uuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucu
caggggggaguacguucgcaagagugaaacuuaaagaaauugacggaaug
gcaccacaagacguggagcgugcgguuuaauuugacucaacacggggaac
uuuaccagauccggacaggaugagauugacagauugaguguucuuucucg
auucccugaaugguggugcauggccgcuuauggucgguggagugauuugu
uugguugauuccgucaacggacgagauccaagcugcccaguagaauucag
aauugcccauaggauagcgcauucggucgaauucuucucugcgggauucc
uuuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcu
ccucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaa
aaacgaucgaaccuacuugaucaaaagaguggggaaaccccggaaucaca
uagacccacuugggaccgaggauugcaauuauuggucgcgcaacgaggaa
ugucucguaggcgcagcucaucaaacugugccgauuacgucccugccauu
uguacacaccgcccgucguuguuuccgaugauggugcaauacaggugauc
ggacaggcgcccgaaaguucaccgauauuucuucaauagaggaagcaaaa
gucguaacaagguagcuguaggggaaccugcagcugggacauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
.<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<
<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>
>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>...........
..............>>>>>>>>...>>....<<<<<......>>>>>...
>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>
>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<
<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<
<....<<<..........>>>..>>>..>....>>>....<<<.<<....
.>>.>>>.....<<<<............>>>.....>.........<<<<
<<<........((.....((..>>)).......))...>>>>>..>>>>>
>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<.
.<..>.>.>>...>...................<...............<
<<<.......>>>>.............>.....<<<<<<<<.......<<
...<.......>..<<<....>>>.....>>......>>>>>..>>>...
........<<..<<<<<<.<<<...>>>.....)))).)))))..>>>>>
>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>........
....<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>.
.....>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<.
.........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.
>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<
<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>......
....<<<<<.<....<<<<........<<.<<<........>>>.>>...
....>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>..
.<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<
<<<.................>>>>....>>>>>>>.....>>>>....<<
<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>
>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<..
...<<..>>..<<<<<<<........>>>>>>>....>........>>>.
..>>>......<....<<<..<..........>..>>>.....>.....>
>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>
>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<
...<.<....>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..
>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)
A2 K5 N6 R8 I9 S10 K11 R15 T23 R26 K27 R55 L116 K118 W119 E124 R138 F140 Q148 N150 Q151 Q152 S153 R154 N155 Y157 K159 Q160 L162 W165 R167 M168 R169 K172 R202 P205 I206
Binding residue
(residue number reindexed from 1)
A1 K4 N5 R7 I8 S9 K10 R14 T21 R24 K25 R53 L114 K116 W117 E122 R136 F138 Q146 N148 Q149 Q150 S151 R152 N153 Y155 K157 Q158 L160 W163 R165 M166 R167 K170 R200 P203 I204
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4FX73|RS3A_LEIMA Small ribosomal subunit protein eS1 (Gene Name=LmjF.35.0400)

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