Structure of PDB 8fkp Chain SA Binding Site BS01

Receptor Information
>8fkp Chain SA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQP
YAVSELAGHQAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAA
SALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLL
NVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLP
MHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNP
YAKTMRRNTILRQARNHKLRVDKAAAAAAAL
Ligand information
>8fkp Chain L1 (length=152) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcua
gcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucg
aacgcacuugcggccccggguucccggggcuacgccugucugagcgucgc
uu
.......................................<<<<<<<<<..
..>>>>.....<.<<<......>>.............>>>..>...>>>.
...<<....>><<<<<<<<<..>>>>>>>>>...................
..
Receptor-Ligand Complex Structure
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PDB8fkp Principles of human pre-60S biogenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		P51 A53 S55 K195 M196
Binding residue
(residue number reindexed from 1)		P50 A52 S54 K165 M166
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkp, PDBe:8fkp, PDBj:8fkp
PDBsum8fkp
PubMed37410842
UniProtP36578|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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