Structure of PDB 5tcu Chain S9 Binding Site BS01

Receptor Information

>5tcu Chain S9 (length=56) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

GITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTTAIKRSRHMA
LLPYVK

Ligand information

>5tcu Chain A (length=1464)

auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacguuagcggcggacgggugaguaacacguggau
aaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccgg
auaauauagugaaagacacuuauagauggauccgcgcugcauuagcuagu
ugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagg
gugaucggccacacuggaacugagacacgguccagacuccuacgggaggc
agcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccg
cgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaac
auaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgu
gccagcagccgcgguaauacguagguggcaagcguuauccggaauuauug
ggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacg
gcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagag
gaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaa
caccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcga
aagcguggggaucaaacaggauuagauacccugguaguccacgccguaaa
cgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgca
uuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaa
uugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaa
cgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauag
agccuuccccuucgggggacaaagugacagguggugcaugguugucguca
gcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuua
agcuuaguugccaucauuaaguugggcacucuaaguugacugccggugac
aaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauu
ugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcg
aggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaa
cucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuac
ggugaauacguucccgggucuuguacacaccgcccgucacaccacgagag
uuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucga
aggugggacaaaugauuggggugaagucguaacaagguagccguaucgga
aggugcggcuggau

.....<<<<..[.(((..>>>>.<<<<.<<<<<...<<<<<<<.....<<
<.<<<...<<..<<........>>>>.......<<........<<<<<<<
..<<...<<<<<<<.<<.<<....<<.<<<....>>>.>>......>>>>
..................>>>>>>>..>>>>>>>>>.<<<....<<<...
<<<<<<<.......>>>>>>>.>>>......>>>..<<<.<<<<....>>
>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>..
.>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>
...<<<<.......<<<....>>>......>>>>................
..<<<<..>>>>.....................<<<<<.((...<<<<<.
....<<.)).>>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<
<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<.<..<
<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...
........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>.>>>..
..<<<<<<<...<...<<<<.........>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<<<..>>>>>>>>>>>>...<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<<<.<<.....<<<<<....>>>
>>...<<<<.....>>.>>.>>.>.>>.<<<.<<<..<<<<<<.......
<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.
.<.<..............................>>.......<<<<...
..>>>>.........>>>>.........>>>...>>>>>>>>>...>>>>
>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<<...<<<...
.>>>...>>...>>>.....>..>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>..
.>>>.>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): K43 I44 R58 T61 K65 H69 Y75
• Binding residue (residue number reindexed from 1): K22 I23 R37 T40 K44 H48 Y54

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
• PDBsum: 5tcu
• PubMed: 28487427
• UniProt: Q2G111|RS18_STAA8 Small ribosomal subunit protein bS18 (Gene Name=rpsR)