Structure of PDB 5tcu Chain S8 Binding Site BS01

Receptor Information
>5tcu Chain S8 (length=80) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDRKVYVGKVVSDKMDKTITVLVETYKTHKLYGKRVKYSKKYKTHDENNS
AKLGDIVKIQETRPLSATKRFRLVEIVEES
Ligand information
>5tcu Chain A (length=1464) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacguuagcggcggacgggugaguaacacguggau
aaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccgg
auaauauagugaaagacacuuauagauggauccgcgcugcauuagcuagu
ugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagg
gugaucggccacacuggaacugagacacgguccagacuccuacgggaggc
agcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccg
cgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaac
auaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgu
gccagcagccgcgguaauacguagguggcaagcguuauccggaauuauug
ggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacg
gcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagag
gaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaa
caccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcga
aagcguggggaucaaacaggauuagauacccugguaguccacgccguaaa
cgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgca
uuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaa
uugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaa
cgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauag
agccuuccccuucgggggacaaagugacagguggugcaugguugucguca
gcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuua
agcuuaguugccaucauuaaguugggcacucuaaguugacugccggugac
aaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauu
ugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcg
aggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaa
cucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuac
ggugaauacguucccgggucuuguacacaccgcccgucacaccacgagag
uuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucga
aggugggacaaaugauuggggugaagucguaacaagguagccguaucgga
aggugcggcuggau
.....<<<<..[.(((..>>>>.<<<<.<<<<<...<<<<<<<.....<<
<.<<<...<<..<<........>>>>.......<<........<<<<<<<
..<<...<<<<<<<.<<.<<....<<.<<<....>>>.>>......>>>>
..................>>>>>>>..>>>>>>>>>.<<<....<<<...
<<<<<<<.......>>>>>>>.>>>......>>>..<<<.<<<<....>>
>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>..
.>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>
...<<<<.......<<<....>>>......>>>>................
..<<<<..>>>>.....................<<<<<.((...<<<<<.
....<<.)).>>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<
<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<.<..<
<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...
........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>.>>>..
..<<<<<<<...<...<<<<.........>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<<<..>>>>>>>>>>>>...<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<<<.<<.....<<<<<....>>>
>>...<<<<.....>>.>>.>>.>.>>.<<<.<<<..<<<<<<.......
<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.
.<.<..............................>>.......<<<<...
..>>>>.........>>>>.........>>>...>>>>>>>>>...>>>>
>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<<...<<<...
.>>>...>>...>>>.....>..>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>..
.>>>.>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		N5 D20 R39 K41 Y42 S43 K45 R67 L69 A71 T72 R74
Binding residue
(residue number reindexed from 1)		N1 D16 R35 K37 Y38 S39 K41 R63 L65 A67 T68 R70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
PDBsum5tcu
PubMed28487427
UniProtQ2FW15|RS17_STAA8 Small ribosomal subunit protein uS17 (Gene Name=rpsQ)

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