Structure of PDB 5tcu Chain S4 Binding Site BS01

Receptor Information
>5tcu Chain S4 (length=113) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARIAGVDIPREKRVVISLTYIYGIGTSTAQKILEEANVSADTRVKDLTDD
ELGRIREVVDGYKVEGDLRRETNLNIKRLMEISSYRGIRHRRGLPVRGQK
TKNNARTRKGPVK
Ligand information
>5tcu Chain A (length=1464) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacguuagcggcggacgggugaguaacacguggau
aaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccgg
auaauauagugaaagacacuuauagauggauccgcgcugcauuagcuagu
ugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagg
gugaucggccacacuggaacugagacacgguccagacuccuacgggaggc
agcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccg
cgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaac
auaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgu
gccagcagccgcgguaauacguagguggcaagcguuauccggaauuauug
ggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacg
gcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagag
gaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaa
caccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcga
aagcguggggaucaaacaggauuagauacccugguaguccacgccguaaa
cgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgca
uuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaa
uugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaa
cgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauag
agccuuccccuucgggggacaaagugacagguggugcaugguugucguca
gcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuua
agcuuaguugccaucauuaaguugggcacucuaaguugacugccggugac
aaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauu
ugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcg
aggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaa
cucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuac
ggugaauacguucccgggucuuguacacaccgcccgucacaccacgagag
uuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucga
aggugggacaaaugauuggggugaagucguaacaagguagccguaucgga
aggugcggcuggau
.....<<<<..[.(((..>>>>.<<<<.<<<<<...<<<<<<<.....<<
<.<<<...<<..<<........>>>>.......<<........<<<<<<<
..<<...<<<<<<<.<<.<<....<<.<<<....>>>.>>......>>>>
..................>>>>>>>..>>>>>>>>>.<<<....<<<...
<<<<<<<.......>>>>>>>.>>>......>>>..<<<.<<<<....>>
>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>..
.>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>
...<<<<.......<<<....>>>......>>>>................
..<<<<..>>>>.....................<<<<<.((...<<<<<.
....<<.)).>>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<
<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<.<..<
<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...
........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>.>>>..
..<<<<<<<...<...<<<<.........>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<<<..>>>>>>>>>>>>...<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<<<.<<.....<<<<<....>>>
>>...<<<<.....>>.>>.>>.>.>>.<<<.<<<..<<<<<<.......
<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.
.<.<..............................>>.......<<<<...
..>>>>.........>>>>.........>>>...>>>>>>>>>...>>>>
>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<<...<<<...
.>>>...>>...>>>.....>..>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>..
.>>>.>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R14 I17 Y21 Y23 G24 G26 T29 I77 Y86 R87 R92 R98 K101 T102 K103 N105 A106 R107 T108 R109
Binding residue
(residue number reindexed from 1)		R13 I16 Y20 Y22 G23 G25 T28 I76 Y85 R86 R91 R97 K100 T101 K102 N104 A105 R106 T107 R108
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
PDBsum5tcu
PubMed28487427
UniProtQ2FW30|RS13_STAA8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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