Structure of PDB 7a5i Chain S3 Binding Site BS01

Receptor Information
>7a5i Chain S3 (length=156) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTGQYGRLFAV
VHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLLGKPL
LGKDLVRVEATVIEKTESWPRIIMRFRKRKNFKKKRIVTTPQTVLRINSI
EIAPCL
Ligand information
>7a5i Chain A3 (length=1485) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauau
aguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaag
gacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugc
aaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaac
agcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaauccc
aaacauauaacugaacuccucacacccaauuggaccaaucuaucacccua
uagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcau
aagccugcgucagaucacacugacaauuaacagcccaauaucuacaauca
accaacaagucauuauuacccucacugucaacccaacacaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
ugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaaggu
agcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacga
ggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaa
gaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuu
auuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucg
gagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaa
gcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuac
gaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagg
uucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggag
uaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggaca
agagaaauaaggccuacuucacaaagcgccuucccccguaaaugauauca
ucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.....<.....<<.....>>....>...>>.>>.........
....<<....>>......................>>>...........<<
<.......>>>...<.<........>.>.<<<<<<.........<<<.<<
..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<.
.<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>
>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>.........................
...........>...>>>>>>........>>>>>>...<<<<<......>
>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<
........<<<<<......>>>>>......<<<...<<<<..........
.............>>>>.......>>>.....<<......>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<................<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>....<<<
.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.......
.<...........<<<<<<.....>>>>>>.....>....>>>....>>.
>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<....
....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<
.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<
<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>
>>....>>.........<<<....>>>............>>>>..>>>>>
>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>
>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>
.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<.
...>>>.>>>>....>>..>>>.>>..<<<.<<<................
.>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.........
.......>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5i Elongational stalling activates mitoribosome-associated quality control.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W61 S103 R104 N118 R169 I171 R173 F174 R175 K176 R177 K178 F180 K182 K183 R184 T188
Binding residue
(residue number reindexed from 1)		W13 S55 R56 N70 R121 I123 R125 F126 R127 K128 R129 K130 F132 K134 K135 R136 T140
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5i, PDBe:7a5i, PDBj:7a5i
PDBsum7a5i
PubMed33243891
UniProtQ7Z2W9|RM21_HUMAN Large ribosomal subunit protein bL21m (Gene Name=MRPL21)

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