Structure of PDB 6gzz Chain S3 Binding Site BS01

Receptor Information
>6gzz Chain S3 (length=78) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQ
HVPVYITENMVGHKLGEFAPTRTYRGHG
Ligand information
>6gzz Chain A3 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<
.<<<..<<<..<<...........................>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<<<...
...>>>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....
<......>.....>>>>>..>>>>>>>>>><<<.....<....<<<<<<<
.......>>>>>>>..>.......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<........>>...>>>>>>
......<...<<....<<<<....>>>>..>>..>.>.>>>>>>..<<<<
......<<<......>>>.....>>>>...<<<<<<......<.<<<<..
...>>>>..>.......>>>>>.>....<<<<<(((...<<<<<.....<
..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((
.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>..>>>...>>>>....<...<<.....<<<<<
<....<<<<<<<....<<........>>.......>>>>>>>........
...<......>.>>>>>>...>>.....>....>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<
<<<<<<....<<<<<<...<<<<<<<........<<........>>....
......<<<<.......................<........>.......
........................<.......<<<<<<<.......<<<<
<<<<....>>>..<<<<......>>>>..>>>>>......<<<<.<<<<<
<<...<..............>.....>>>>>>>.....<<<<<....>>>
>>........>>>>.......>.>>>...>>>.....>......>>.>>.
....>>>>>>>......<<<<.........<...<...<<<<....>>>>
...>.....>.........>>>>......<....<<<<<<<........>
>>>>>>....>.....>>>>>>.....<<<<<............>>>>>.
...........>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<
<<<<<<<<<...<..<<.....<........>..>>..>..>>>>>>>>>
>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.13 Å
Binding residue
(original residue number in PDB)		K7 F10 V11 H14 K18 E21 W34 S35 R36 R37 Y52 G54 K55 K70 G72 T77 R78 T79 Y80 R81 G82
Binding residue
(residue number reindexed from 1)		K1 F4 V5 H8 K12 E15 W28 S29 R30 R31 Y46 G48 K49 K64 G66 T71 R72 T73 Y74 R75 G76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
PDBsum6gzz
PubMed30301898
UniProtQ5SHP2|RS19_THET8 Small ribosomal subunit protein uS19 (Gene Name=rpsS)

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