Structure of PDB 8wq2 Chain S27E Binding Site BS01

Receptor Information

>8wq2 Chain S27E (length=59) Species: 330779 (Sulfolobus acidocaldarius DSM 639)

MKAKFKILIPEPKSKFIRVKCRQCNNEQVIFSNATFPVRCLSCGAQIVIP
KGGKAKIEG

Ligand information

>8wq2 Chain A16S (length=1328)

auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc
augggagucuuacacucccggguaagggaguguggcggacggcugaguaa
cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga
uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu
auaggcuauuucccguuuguagccgcccgaggauggggcuacggcccauc
aggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccg
uggaagcgggagccuccaguugggcacugagacaagggcccaggcccuac
ggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgc
uaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggg
gaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuc
cgcgaguggucggggugauuacugggccuaaagcgccuguagccggccca
ccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgaua
cuggugggcuagggggcgggagaggcgggggguacucccggaguaggggc
gaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuag
aacgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacga
ugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaa
gccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaa
ggaauuggcgggggagcaccacaagggguggaaccugcggcucaauugga
gucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcu
aacgaccuugccugacucgcggagaggaggugcauggccgucgccagcuc
guguugugaaauguccgguuaaguccggcaacgagcgagacccccacccc
uaguugguauucuggacuccgguccagaaccacacuagggggacugccgg
cguaagccggaggaaggagggggccacggcaggucagcaugccccgaaac
ccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucga
aagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaa
acccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccg
cggugaauacgucccugcuccuugcaca

...<<<<..[..(((.>>>>.<<<<<<<.......<<<.<<......<<<
.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<..<...
..<<<<<<<..<<...<<<<<<..<<<<<....<<<<........>>>>.
....>>>>>...<<<<<<<...<<......>>..>>>>>>>.....<<<<
<<................>>>>>>..>>>>>>..>>>>>>>>>.<<<...
.<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<
<....>>>>...>>>>>>>.<<<<<............>>>>>.<<<<...
.>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>
>..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>
>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>
>>>....>>>>>>>..........<<<((.....<<<<...<<<.<<<<<
<<.<<..<<<<<......<<<<<<<.....>>>>>>>....>>>>>....
>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<.....<<...
.....>>........>>>>>>.>>>.......<<....>>.>>>>>>>..
..>>>.>>>...>>>...>>>>....<<<<<<...>>>>>>.........
.<<<<<<..<<<.<<<<<<<<<<.....>>>>>>>>>>.>>>...<<..)
)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)
))..]....<..<<<<<<...<.<<<<<...<<<<<<<<<<......<<.
.......>>..........<<<<......<<..........<.<.<<<..
.....>>>.>.>........>>...<<.<<...<<<<<<<<.....<<<<
<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<
<<...<....<..<<<<....>>>>.>.....>..>>>>>>.....<<<<
<....>>>>>........>>>>>.....>>.>>>...>>>.>>>>.....
>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<...
...>>>..>>....>>.....>>>>>>>......<....<<<<<<<....
....>>>>>>>....>......>>>>>....<<<<<<<<.......>>>>
>>>>......>....>>>>>>.>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wq2 Structural basis of translation inhibition by a valine tRNA-derived fragment
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): M1 K2 A3 K4 F5 K6 P12 K13 S14 N33 F36 G52 K54
• Binding residue (residue number reindexed from 1): M1 K2 A3 K4 F5 K6 P12 K13 S14 N33 F36 G52 K54

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:8wq2, PDBe:8wq2, PDBj:8wq2
• PDBsum: 8wq2
• PubMed: 38599770
• UniProt: Q4J9B1|RS27_SULAC Small ribosomal subunit protein eS27 (Gene Name=rps27e)