Structure of PDB 7azo Chain S20B Binding Site BS01

Receptor Information
>7azo Chain S20B (length=99) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMR
KAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA
Ligand information
>7azo Chain 16SB (length=1508) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagaca
ugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggug
aguaacgcgugggugaccuacccggaagagggggacaacccggggaaacu
cgggcuaaucccccauguggacccgccccuugggguguguccaaagggcu
uugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaa
uggcccaccaaggcgacgacggguagccggucugagaggauggccggcca
caggggcacugagacacgggccccacuccuacgggaggcagcaguuagga
aucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaag
aagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgag
gggacugacgguaccgggguaauagcgccggccaacuccgugccagcagc
cgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaag
ggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccg
ugggggagcgugggauacgcucaggcuagacggugggagaggguggugga
auucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaugg
cgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggg
gagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcg
cuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccg
ccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcc
cgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccu
uaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccc
gcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugcc
gugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguu
gccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggag
gaaggaggggacgacgucuggucagcauggcccuuacggccugggcgaca
cacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagc
uaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccc
caugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaau
acguucccgggccuuguacacaccgcccgucacgccaugggagcgggcuc
uacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgu
gacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga
ucaccucc
...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.
<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.
......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>
>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<.
..>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<....
...>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>
>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>...
.....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<....
..<<<<....>>>>.....>>>>....<<<<<........<<<<.....>
>>>..........>>>>>......<<<<<(((...<<<<<.....<<.))
)>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((....
.<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>
>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<...
.<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<
<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<.
..<<...<<<<.........>>>>...>>>>>>>>..........<<<<<
<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>
>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<
<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........
..<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.
.....>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<
....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..
<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>..
......>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.
>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>
....>>>.....>>>>>>>......<....<<<<<<<........>>>>>
>>....>.....>>>>>>....<<<<<<<..........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<
<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>
..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7azo Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R8 S11 K14 R15 H16 R17 S19 R22 R23 N26 A28 S31 K34 T35 K38 K39 E60 S61 D64 K65 S70 H73 N75 A78 R79 K81 S82 R83 M85 R86 R89 G103 L104 S105
Binding residue
(residue number reindexed from 1)		R1 S4 K7 R8 H9 R10 S12 R15 R16 N19 A21 S24 K27 T28 K31 K32 E53 S54 D57 K58 S63 H66 N68 A71 R72 K74 S75 R76 M78 R79 R82 G96 L97 S98
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7azo, PDBe:7azo, PDBj:7azo
PDBsum7azo
PubMed36827973
UniProtP80380|RS20_THET8 Small ribosomal subunit protein bS20 (Gene Name=rpsT)

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