Structure of PDB 7azo Chain S13A Binding Site BS01

Receptor Information
>7azo Chain S13A (length=119) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTVAGK
Ligand information
>7azo Chain 16SA (length=1512) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagaca
ugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgg
gugaguaacgcgugggugaccuacccggaagagggggacaacccggggaa
acucgggcuaaucccccauguggacccgccccuugggguguguccaaagg
gcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggg
uaauggcccaccaaggcgacgacggguagccggucugagaggauggccgg
ccacaggggcacugagacacgggccccacuccuacgggaggcagcaguua
ggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagg
aagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgac
gaggggacugacgguaccgggguaauagcgccggccaacuccgugccagc
agccgcgguaauacggagggcgcgagcguuacccggauucacugggcgua
aagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaa
ccgugggggagcgugggauacgcucaggcuagacggugggagaggguggu
ggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccga
uggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgu
ggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugc
gcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcg
ccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggg
gcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaa
ccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugc
cccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgu
gccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguua
guugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgg
gaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcg
acacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggg
agcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccga
ccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggug
aauacguucccgggccuuguacacaccgcccgucacgccaugggagcggg
cucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcc
cgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcu
ggaucaccuccu
...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.
<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......
<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<....
..>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<
<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.
......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>
........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>....<<<<<........<<<<...
..>>>>..........>>>>>......<<<<<(((...<<<<<.....<<
.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.
....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....
>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<
....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.........
..<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<
<<...<<...<<<<.........>>>>...>>>>>>>>..........<<
<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<
<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.....
.....<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....
<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<
<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<
<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>
>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...
>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>.
.>>....>>>.....>>>>>>>...........<<<<<<<........>>
>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>.
.....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<
<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>
>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>
............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7azo Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K13 R14 V17 Y21 Y23 G24 I25 G26 R29 R44 V74 N77 Y87 R88 R91 H92 P97 V98 R99 G100 Q101 R102 T103 R104 T105 N106 R108 T109 R110 K111 R114 K115 T116 K120
Binding residue
(residue number reindexed from 1)		K12 R13 V16 Y20 Y22 G23 I24 G25 R28 R43 V73 N76 Y86 R87 R90 H91 P96 V97 R98 G99 Q100 R101 T102 R103 T104 N105 R107 T108 R109 K110 R113 K114 T115 K119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7azo, PDBe:7azo, PDBj:7azo
PDBsum7azo
PubMed36827973
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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