Structure of PDB 8wkp Chain S12P Binding Site BS01

Receptor Information
>8wkp Chain S12P (length=143) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKSPKGLFAARKLRLKRLKFSWSQRSFKRRMLALKEKFDPLEGAPMARG
IVLEKVGIESRQPNSAVRKAVRVQLVKNGRIVTAFVPGDGGVNFIDEHDE
VVIAGIGGTLGRSMGDLPGVRYKVVMVNGVSLDALYKGKKQKP
Ligand information
>8wkp Chain A16S (length=1325) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc
augggagucuuacacucccggguaagggaguguggcggacggcugaguaa
cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga
uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu
auaggcuauuucccguuuguagcgcccgaggauggggcuacggcccauca
ggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccgu
ggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacg
gggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcu
accccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcggggg
aauaagcggggggcaagucuggugucagccgccgcgguaauaccagcucc
gcgaguggucggggugauuacugggccuaaagcgccuguagccggcccac
caagucgccccuuaaaguccccggcucaaccggggaacugggggcgauac
uggugggcuagggggcgggagaggcgggggguacucccggaguaggggcg
aaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuaga
acgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacgau
gcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaag
ccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaag
gaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggag
ucaacgccuggaaucuuaccggggagaccgcaguaugacggccaggcuaa
cgaccuugccugacucgcggagaggaggugcauggccgucgccagcucgu
guugugaaauguccgguuaaguccggcaacgagcgagacccccaccccua
guugguauucuggacuccgguccagaaccacacuagggggacugccggcg
uaagccggaggaaggagggggccacggcaggucagcaugccccgaaaccg
ggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaag
ggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacc
cgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcgg
ugaauacgucccugcuccuugcaca
...<<<<<.[.((((>>>>>.<<<<<<<<......<<<.<<......<<<
.<<<...<...<<<<<<<<......>>>>>>>>.>......<<<......
..<<<<<<<..<<...<<<<<<<.<<<<.....<<<<........>>>>.
.....>>>>...<<<<<<.<<.<<......>>>>.>>>>>>........<
<<................>>>...>>>>>>>..>>>>>>>>>.<<<....
<<....<<<<<<<.......>>>>>>>..>>......>>>..<<<<<<<<
....>>>>...>>>>.>>><<<<<............>>>>>.<<<<....
>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>
..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>>
.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>
>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<
<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>
>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<....
....>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>...
.>>>.>>>...>>>...>>>>...<<<<<<.....>>>>>>.........
<<<<<<..<<<.<<<<<<.<<<.....>>>.>>>>>>.>>>...<<..))
>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))
)).].<.....<<<<<...<<.<<<<<..<<.<<<<<<<.......<<..
......>>..........<<<...................<<.<<<....
...>>>.>>..............<<.<<....<<<<<.......<<<<<<
............<<<<......>>>>..>>>>>>....<<<...<<<<<<
<..........<<<<....>>>>.........>>>>>>>.....<<<<<.
...>>>>>.........>>>.........>>>...>>..>>>>.....>>
>....>.>>>>>>>>.....<<<.<<<.......<..<...<<<<....>
>>>...>....>......>>>.>>>...........<<<<<<<.......
.>>>>>>>...........>>>>>....<<<<<<<<.......>>>>>>>
>......>>....>>>>>...>...
Receptor-Ligand Complex Structure
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PDB8wkp Structural basis of translation inhibition by a valine tRNA-derived fragment
Resolution4.62 Å
Binding residue
(original residue number in PDB)
G3 K5 S6 P7 K8 G9 F11 R14 K15 K19 R20 F23 S24 W25 S26 Q27 R28 F30 K31 R33 M34 L37 F41 A47 P48 M49 R51 R63 Q64 P65 N66 S67 A68 V69 R70 V78 K79 A106 G107 L112 G113 R114 M116 D118 R123 K125 M128 S133 D135 A136 K139 K141
Binding residue
(residue number reindexed from 1)
G1 K3 S4 P5 K6 G7 F9 R12 K13 K17 R18 F21 S22 W23 S24 Q25 R26 F28 K29 R31 M32 L35 F39 A45 P46 M47 R49 R61 Q62 P63 N64 S65 A66 V67 R68 V76 K77 A104 G105 L110 G111 R112 M114 D116 R121 K123 M126 S131 D133 A134 K137 K139
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8wkp, PDBe:8wkp, PDBj:8wkp
PDBsum8wkp
PubMed38599770
UniProtP11524|RS12_SULAC Small ribosomal subunit protein uS12 (Gene Name=rps12)

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