Structure of PDB 7azs Chain S11A Binding Site BS01

Receptor Information
>7azs Chain S11A (length=116) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYA
AQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVD
DTPVPHNGCRPKKKFR
Ligand information
>7azs Chain 16SA (length=1511) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagaca
ugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgg
gugaguaacgcgugggugaccuacccggaagagggggacaacccggggaa
acucgggcuaaucccccauguggacccgccccuugggguguguccaaagg
gcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggg
uaauggcccaccaaggcgacgacggguagccggucugagaggauggccgg
ccacaggggcacugagacacgggccccacuccuacgggaggcagcaguua
ggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagg
aagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgac
gaggggacugacgguaccgggguaauagcgccggccaacuccgugccagc
agccgcgguaauacggagggcgcgagcguuacccggauucacugggcgua
aagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaa
ccgugggggagcgugggauacgcucaggcuagacggugggagaggguggu
ggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccga
uggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgu
ggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugc
gcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcg
ccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggg
gcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaa
ccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugc
cccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgu
gccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguua
guugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgg
gaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcg
acacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggg
agcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccga
ccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggug
aauacguucccgggccuuguacacaccgcccgucacgccaugggagcggg
cucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcc
cgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcu
ggaucaccucc
...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.
<<<..<<<..<<.<<<<<<<<<.<...>.>>>>>>>>>.>>>>>......
<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<....
..>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<
<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.
......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>
........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>....<<<<<........<<<<...
..>>>>..........>>>>>......<<<<<(((...<<<<<.....<<
.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.
....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....
>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<
....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.........
..<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<
<<...<<...<<<<.........>>>>...>>>>>>>>..........<<
<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<
<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.....
.....<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....
<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<
<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<
<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>
>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...
>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>.
.>>....>>>.....>>>>>>>...........<<<<<<<........>>
>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>.
.....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<
<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>
>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7azs Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y20 H22 N26 N27 I29 T31 G37 N38 P39 W42 S44 G46 G52 S53 K55 R85 P115 H116 N117 G118 C119 R120 K122 K123 K124
Binding residue
(residue number reindexed from 1)		Y10 H12 N16 N17 I19 T21 G27 N28 P29 W32 S34 G36 G42 S43 K45 R75 P105 H106 N107 G108 C109 R110 K112 K113 K114
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7azs, PDBe:7azs, PDBj:7azs
PDBsum7azs
PubMed36827973
UniProtP80376|RS11_THET8 Small ribosomal subunit protein uS11 (Gene Name=rpsK)

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